Editor—Delirium is a common, morbid, and costly complication of surgery among older adults.1Boone M.D. Sites B. von Recklinghausen F.M. Mueller A. Taenzer A.H. Shaefi S. Economic burden postoperative neurocognitive disorders US Medicare patients.JAMA Netw Open. 2020; 3e208931Crossref PubMed Scopus (16) Google Scholar,2Berian J.R. Zhou L. Russell M.M. et al.Postoperative delirium as target for s...

BACKGROUND There is limited information on the impact on perioperative fluid intervention on complications and length of hospital stay following pancreaticoduodenectomy. Therefore, we conducted a detailed analysis of fluid intervention in patients undergoing pancreaticoduodenectomy at a university teaching hospital to test the hypothesis that a restrictive intravenous fluid regime and/or a neut...

Editor—Perioperative fluid optimization is an established technique in reducing morbidity after major surgery. Hypovolaemia is associated in particular with increased gut morbidity and increased length of hospital stay. Excessive fluid administration produces the clinical picture of pulmonary, peripheral, and gut oedema with associated morbidity and mortality. Intraoperative determination of fl...

PURPOSE Surgical removal of solid primary tumors is an essential component of cancer treatment. Surgery-induced dysfunction in natural killer (NK) cells has been linked to the development of metastases in animal models and patients with cancer. We investigated the activation of NK cells using influenza vaccine in the perioperative period to eradicate micrometastatic disease. EXPERIMENTAL DESI...

Optimal perioperative fluid management is an important component of Enhanced Recovery After Surgery (ERAS) pathways. Fluid management within ERAS should be viewed as a continuum through the preoperative, intraoperative, and postoperative phases. Each phase is important for improving patient outcomes, and suboptimal care in one phase can undermine best practice within the rest of the ERAS pathwa...

This review summarises the new insights into the physiology of perioperative fluid therapy and analyses recent studies of the safety of the use of HES solutions in the fluid management of critically ill patients. This analysis reveals a number of methodological issues in the three major studies that have initiated the recommendation of the European Medicine Agency to ban hydroxyethyl starches f...

This review summarises the new insights into the physiology of perioperative fluid therapy and analyses recent studies of the safety of the use of HES solutions in the fluid management of critically ill patients. This analysis reveals a number of methodological issues in the three major studies that have initiated the recommendation of the European Medicine Agency to ban hydroxyethyl starches f...

Background: Blood loss during and immediately after total knee arthroplasty (TKA) is among the most challenging concerns. It has been demonstrated that Tranexamic acid (TXA) can help to reduce perioperative blood loss. TXA can be used as an oral, topical or intravenous injection. Many studies evaluated the effectiveness of each route of administration but few works on a comparison between them....

BACKGROUND The purpose of this retrospective study was to present our assessment of modifiable perioperative factors for major cardiac and cerebrovascular events (MACCE). METHODS This study included an unselected cohort of patients with head and neck cancer (n = 456) treated in Turku University Hospital between 1999 and 2008. RESULTS Perioperative and postoperative univariate predictors of ...