OBJECTIVES To present a rare case of facial nerve paraganglioma and novel use of a processed allograft for facial nerve reconstruction. STUDY DESIGN Case report and review of the literature. METHODS A 34 year old female presented with progressive onset right sided facial palsy for 5 months. CT and MRI demonstrated an irregular mass in the right facial nerve canal from the intratympanic segm...

objectives to compare an out-of-plane interscalene catheter technique to the in-plane technique in a randomized clinical trial. patients and methods eighty-four patients undergoing open shoulder surgery were randomized to either the in-plane or out-of-plane ultrasound-guided continuous interscalene technique. the primary outcome was vas pain rating at 24 hours. secondary outcomes included pain ...

Aims and Objectives. The aim of this study was to evaluate the effectiveness of vein conduit in nerve repair compared with isolated nerve graft. Materials and Methods. This retrospective study was conducted at author's centre and included a total of 40 patients. All the patients had nerve defect of more than 3 cm and underwent nerve repair using nerve graft from sural nerve. In 20 cases, vein c...

Although peripheral nerve injury is a common consequence of trauma or surgery, there are insufficient means for repair. In particular, there is a critical need for improved methods to facilitate regeneration of axons across major nerve lesions. Here, we engineered transplantable living nervous tissue constructs to provide a labeled pathway to guide host axonal regeneration. These constructs con...

Currently the clinical standard of care for treatment of extensive peripheral nerve damage is the autograft, which consists of a donor nerve from the patient implanted to bridge the site of injury. This technique, although providing a non-immunogenic solution to guide in nerve regeneration, is limited by several constraints including donor site morbidity. To address these concerns, our lab has ...

The authors briefly present the methods of reconstruction of peripheral nerve gaps. Of these methods, the reconstruction with nerve allografts is reviewed mainly in what concerns the ways to achieve host tolerance for the allograft. The authors underline the fact that, for the recipient it is better to suppress the graft antigenicity than to suppress the host immune response. Further, the autho...

Xenotransplantation offers a potentially unlimited source for tissues and organs for transplantation, but the strong xenoimmune responses pose a major obstacle to its application in the clinic. In this study, we investigate the rejection of mouse peripheral nerve xenografts in rats. Severe intragraft mononuclear cell infiltration, graft distension, and necrosis were detected in the recipients a...

Facial nerve palsy may represent an important complication of head trauma; yet, an adequate surgical treatment can reduce negative effects of such injuries. The surgical treatment usually consists of nerve decompression, nerve anastomosis and graft technique with n. auricularis magnus. In this study a retrospective analysis of the patients treated from the traumatic facial palsy in a ten-year p...

ObjectiveComprehensive functional, histomorphometrical and immunohistochemical assessment of sciatic nerve regeneration through an inside-out vein graft in rat. DesignExperimental in vivo study. AnimalsFiftyfour healthy male White Albino rats. ProceduresThe rats were divided into three experimental groups (n=18), randomly: Sham-operation (NC), Transected control (TC) and Inside-out vein graft (...