In Saccharomyces cerevisiae, genes near telomeres are transcriptionally repressed, a phenomenon termed telomere position effect (TPE). Yeast telomeres cluster near the nuclear periphery, as do foci of proteins essential for TPE: Rap1p, Sir2-4p, and yKu70p/yKu80p. However, it is not clear if localization of telomeres to the periphery actually contributes to TPE. We examined the localization patt...

BACKGROUND In comparison with many nuclear proteins, the movement of chromatin in nuclei appears to be generally constrained. These restrictions on motion are proposed to reflect the attachment of chromatin to immobile nuclear substructures. RESULTS To gain insight into the regulation of chromosome dynamics by nuclear architecture, we have followed the movements of different sites in the huma...

The paper develops an argument concerning the pluralistic character of the process of globalization, as contrasted with the conventional account that sees global processes creating uniformity and convergence. This alternative account is based on a series of case studies of latecomer and newcomer multinational corporations, such as Acer, Ispat International, Li & Fung and the Hong Leong Group; a...

Scholars who adopted de-centring as a strategy for globalising IR have embraced the notions of ‘centre’ and ‘periphery’ to highlight structural inequalities between North America Western Europe rest world in production knowledge about politics. In doing so, however, scholarship has portrayed if it is new entrant ‘international’. Yet, such presumption not spirit IR, which views periphery ‘consti...

Institutional economics approach reveals that institutions are essential in increasing social welfare by
 comprehensively addressing and economic life. At the same time, institutional approach
 proceeds similarly to problems discussed development literature. This study evaluates the
 developmental differences between countries core, semi-periphery periphery according to
 qua...