Abstract The alarmin S100 calcium-binding protein A9 (S100A9) plays a role in the immunopathology of lung diseases such as asthma and pneumonia. We hypothesized that acute pneumonia induced by S. pneumoniae exacerbates through S100A9 induction increase neutrophilic inflammation NET production. C57BL/6 Wild Type (WT) animals mice deficient for expression (S100A9 −/−) were sensitized challenged w...

perivascular epithelioid cell tumor (pecoma) is composed of hmb45+ epithelioid cells with clear to granular cytoplasm and perivascular distribution. we describe a uterine pecoma in a 33 years old woman where tumor cells were positive for hmb45 but negative for epithelial markers and negative or positive for smooth muscles markers.

PURPOSE To determine if the architectural features revealed by magnetic resonance microscopy (MRM) allow one to detect microscopic abnormalities associated with neuroinflammation in fixed brain sections from animals with experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). MATERIALS AND METHODS Imaging was performed at the Center for In Vivo Microscopy (...

OBJECTIVE To investigate the pathophysiology of perivascular mononuclear cell infiltrates observed in skeletal muscle from patients with systemic lupus erythematosus (SLE). METHODS Immunocytochemical techniques were used to examine frozen 5 microns sections from the quadriceps needle muscle biopsy specimens of 14 patients with SLE (including seven with infiltrates) for the expression of the c...

Aim : to present a clinical case of pancreatic PEComa with liver metastases an emphasis on morphological features, radiology diagnostic methods and features treatment tactics, allowing practitioners get idea about this rare mesenchymal tumors composed “perivascular epithelioid cells”, review literature data PEComa, including 32 author's cases. General statements . A 22-year-old woman who was su...

An evaluation of electrocardiographic tracings as an index of myocar(lial (lamage in survivors of subacute bacterial endocarditis wvas undertaken in a study of 76 fatal cases of the disease. Anatomic changes, plresent in all, inclu(ledl myocarditis, perivascular infiltration and fibrosis, Aschoff bodies, infarets, and intravascular emboli. Electrocardiographic tracings revealed changes which co...

The acute peripheral neuropathy as one of hypereosinophilic syndrome is known to be a rare disorder. The authors experienced a dramatic case with acute peripheral neuropathy, hypereosinophilia in peripheral blood, and the positive anti-GM1 antibodies. The serum protein electrophoresis showed a diffusely increased gamma-globulin region and the polyclonal gammopathy was found by the immunoelectro...

Diagnostic criteria for neuromyelitis optica (NMO) state that there should be no active disease outside the optic nerves and spinal cord. However, several cases have been described with symptomatic brain involvement. We describe an autopsy case of a patient with NMO and symptomatic involvement of the brain. The histopathology of the brain lesions is typical for NMO, with extensive macrophage in...

The infiltration of immune cells in the central nervous system is a common hallmark in different neuroinflammatory conditions. Accumulating evidence indicates that resident glial cells can establish a cross-talk with infiltrated immune cells, including T-cells, regulating their recruitment, activation and function within the CNS. Although the healthy CNS has been thought to be devoid of profess...