نتایج جستجو برای: ph sensitive nanoparticles
تعداد نتایج: 539402 فیلتر نتایج به سال:
Doxorubicin (DOX) is known as a chemotherapeutic agent for treating variety of cancers. However, due to non-specific distribution, DOX causes severe side effects, leading the limitation its clinical application. In this study, pH-sensitive redox nanoparticles containing were studied form drug-coated with size about 40-60 nm that increases concentration drugs accumulated at tumor site in respons...
The oral route is the preferred route for drug delivery, among oral delivery Intestine and colon drug delivery have been used for molecules aimed at local treatment of colonic diseases such as Colon Cancer, Polyp, Colorectal, Crohn’s Disease, Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC) etc. and for delivery of molecules susceptible to enzymatic degradation such as peptides. There ...
Smart drug delivery systems that are triggered by environmental conditions have been developed to enhance cancer therapeutic efficacy while limiting unwanted effects. Because cancer exhibits abnormally high local acidities compared to normal tissues (pH 7.4) due to Warburg effects, pH-sensitive systems have been researched for effective cancer therapy. Chitosan-based intelligent theragnosis nan...
BACKGROUND The aim of present study was to develop the novel methods for chemical and physical modification of superparamagnetic iron oxide nanoparticles (SPIONs) with polymers via covalent bonding entrapment. These modified SPIONs were used for encapsulation of anticancer drug doxorubicin. METHOD At first approach silane-grafted magnetic nanoparticles was prepared and used as a template for ...
There is a need for new tools to better quantify intracellular delivery barriers in high-throughput and high-content ways. Here, we synthesized a triple-fluorophore-labeled nucleic acid pH nanosensor for measuring intracellular pH of exogenous DNA at specific time points in a high-throughput manner by flow cytometry following non-viral transfection. By including two pH-sensitive fluorophores an...
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