agility is the fundamental characteristic of a supply chain needed for survival in turbulent markets, where environmental forces create additional uncertainty resulting in higher risk in the supply chain management. in addition, agility helps providing the right product, at the right time to the consumer. the main goal of this research is therefore to promote supplier selection in pharmaceutica...

It is over 20 years since the first fragment-based discovery projects were disclosed. The methods are now mature for most 'conventional' targets in drug discovery such as enzymes (kinases and proteases) but there has also been growing success on more challenging targets, such as disruption of protein-protein interactions. The main application is to identify tractable chemical startpoints that n...

The practicable application of 3D printing in the pharmaceutical and food sectors directly relates to preparation highly stable bioactive printable inks. Here, three different polyphenols (rosemary polyphenols, thyme basil polyphenols) were individually grafted onto soy protein isolate through a free-radical grafting method produce precursor ink develop printed plant-based cheese. morphological...

During first year of steroid usage, osteocyte necrosis and blood vessel blockage may occur, which subsequently may produce steroid-induced bone infarction (SIBI) resulting in painful movement of patient. For treatment of SIBI, pharmaceutical strategy is the basic approach. It involves the use of various pharmacologically active compounds including bisphosphonates, hyperbaric oxygen (HBO), coenz...

Nahrung 42 (1998) Nr. 3/4, S. 252–253 © WILEY-VCH Verlag GmbH, D-69451 Weinheim, 1998 0027-769X/98/0304-0252$17.50+.50/0 The Hebrew University of Jerusalem, School of Pharmacy, Department of Pharmaceutical Chemistry and *Department of Pharmacy, Jerusalem, Israel. Correspondence to: Dr. Marina Zemser, The Hebrew University of Jerusalem, School of Pharmacy, Department of Pharmaceutical Chemistry,...

www.pharmtech.com yophilization or freeze-drying is often used to stabilize various pharmaceutical products, including virus vaccines, protein and peptide formulations, liposome, and small-chemical drug formulations (1–4). Often a pharmaceutical product may be susceptible to physical and chemical degradation when stored as a ready-to-use solution. The goal of the formulations scientist is to id...

MS for the evaluation of endocrine disrupting chemicals in H295R cells David Tonoli, Petra Strajhar, Julien Boccard, Denis Hochstrasser, Fabienne Jeanneret, Alex Odermatt, Serge Rudaz 1 School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland 2 Department of Human Protein Sciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland Swiss C...

Introduction The study of the human serum proteome is an area of great interest, especially the pharmaceutical potential for identifying disease biomarkers. The study of this proteome is challenging because most of the proteins of pharmaceutical interest appear at low concentrations. Albumin and IgGs make up greater than 70% of the proteins in serum. Depletion of these high abundance proteins a...

Expression of recombinant proteins in Escherichia coli (E. coli) remains the most popular and cost-effective method for producing proteins in basic research and for pharmaceutical applications. Despite accumulating experience and methodologies developed over the years, production of recombinant proteins prone to aggregate in E. coli-based systems poses a major challenge in most research applica...