نتایج جستجو برای: pharmacogenetic
تعداد نتایج: 2484 فیلتر نتایج به سال:
Beyond these insights there are further applications and future challenges Sir, Insights into the genetic susceptibility to Crohn's disease (CD) 1 would be incomplete without recognition that the unrivalled success of azathioprine in inducing and maintaining remission in corticoster-oid-dependent CD 2 ought to go hand in hand with a wider application of pharmacogenetic testing 3 so as to optimi...
What have we learned? Pharmacogenetics, heritable variation in response to xenobiotics, is present in all forms of life. Initially, human data perhaps have created the most excitement, and they provide much biochemical detail. However, if we look at pharmacogenetic variation of insects and bacteria, we see it as a characteristic of populations; individuals with inborn resistance to various toxi...
Learning Objectives At the end of this activity, participants should be able to: explain basic pharmacogenomic and pharmacogenetic concepts. explain how genetic variation in proteins, including drug transporters and drug metabolizing enzymes, affect drug metabolism and drug response. discuss the availability of evidence-based guidelines and utilize them for the selection of drug therapy. ...
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promis...
The topics discussed in this article are concerned with studying genomic polymorphism and identifying new therapeutic targets, the role of genetics in preclinical and clinical drug development, and cultural, regulatory and logistical aspects of the development of pharmacogenetics in France. The conclusions are that from a physiological, biochemical or genomic point of view, the study of human g...
One of the main goals to improve chemotherapy in cancer patients is to increase the safety while not reducing the efficacy of therapy. Cancer chemotherapy is mainly empirical with the majority of cytotoxic agents given at a fixed dosage based on either body surface area or weight. These compounds have a narrow therapeutic index, and there is no simple index for monitoring pharmacological effect...
Pharmacists must consider all factors when dosing medication for a patient. Until recently, however, one key piece to this puzzle was missing--genetics. This invisible piece of the puzzle can now be utilized with pharmacogenetic testing. By using pharmacogenetic testing, the compounding pharmacist will be able to better predict disease risk as well as the pharmacodynamic and pharmacokinetic act...
Pharmacogenetics is a growing field of research that focuses on the interaction between genetics and drug therapy. Relationships between genetic variation and drug effect have been observed for a growing number of commonly used drugs. Validation studies may soon define the use of these relationships in clinical practice, moving the field toward routine application. Currently, there are only a f...
n engl j med 360;8 nejm.org february 19, 2009 813 medicines should be an overarching goal for pharmacotherapy over the next decade. Pharmacogenetics has the potential to increase benefit and reduce harm in people whose drug responses are not “average.” In some cases, randomized, controlled trials will be needed to determine whether pharmacogenetic testing is worthwhile; in others, less rigorous...
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