نتایج جستجو برای: phenyl ethanol amine
تعداد نتایج: 151316 فیلتر نتایج به سال:
The title compound, C(21)H(22)NO(3)P, was synthesized from the reaction of (C(6)H(5)O)(2)P(O)(Cl) and S-1-phenyl-propyl-amine (1:2 mole ratio) at 273 K, followed by removal of the S-1-phenyl-propyl-amine hydro-chloride by-product by dissolving in H(2)O. The P atom is located in a distorted tetra-hedral environment. The bond angles at the P atom vary from 99.51 (12) to 116.68 (12)°. The sp(2) ch...
Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.
TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) is a novel multitargeted, orally active protein tyrosine kinase inhibitor. The inhibition constants (K(i)) of TG100435 against Src, Lyn, Abl, Yes, Lck, and EphB4 range from 13 to 64 nM. TG100435 has systemic clearance values of 20.1, 12.7, and 14.5 ml/min/kg and oral bioavailabilit...
Polyurea-urethanes are one of the polyurethane categories that causes better phase separation due to increasing the hard segment length and non-covalent interactions. In this research, hydroxyl-terminated polybutadiene based polyurea-urethanes have been synthesized via one-pot polymerization of triethanol amine triflouroborate comlex as cross-linker, isophoron diisocyanate as curing agent and v...
A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...
A new unsymmetric thioether diamine N - ( 2 - ( 2 - aminophenylthio) ethyl) benzene - 1 , 2 - diamine was prepared through the nucleophilic substitution of cysteaminium chloride with 1 - chloro - 2 - nitrobenzene and then the nitro groups of prepared compuond converted to the amine by zinc powder and ammonium chloride. Then, unsymmetric Schiff bass ligand 2 - ((( 2 - (( 2 - (( 2 - (( 2 - hydrox...
A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...
Synthesis of Substituted 2-[(2-chloro-4-oxo-3-phenylazetidin-1-yl)amino]-1-methyl-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile(6a-r) and 1-methyl-6-oxo-2-[(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)amino]-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile (7a-o)Derivatives was completed using aromatic aldehyde, ethylcyanoacetate thiourea in absolute ethanol as per the standard procedure.The complet...
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