Five Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) patients with additional chromosome abnormalities at diagnosis have been followed during Imatinib therapy. In all, the Ph chromosome disappeared, while the 5 cases, additional abnormalities [dup(1); del(5), +8 (2 patients) and +14] persisted in the subsequent studies, performed over a period of 11 to 49 months, either al...

The author discusses both the standards of care and more controversial areas in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.

Only the maternally derived allelic form of the X-chromosome-linked enzme phosphoglycerate kinase (PGK-1) is observed in the mural trophoblast of heterozygous female progeny in F1 and backcross matings. We have demonstrated that this expression of the maternally derived PGK-1 is not a result of maternal tissue contamination nor of selection of cells expressing the maternal X chromosome (Xm). Ou...

Bilateral proliferative retinopathy is a rare complication of chronic myeloid leukemia (CML) as few case reports have been published to date. In this report, 32-year old diabetic female presented with history bilaterally decreased vision. Ophthalmologic examination showed bilateral (i.e., retinal detachment, vitreous hemorrhage, pre-retinal fibrosis and the presence peripheral capillary dropout...

The Breakpoint Cluster Region is a protein encoded by the BCR gene with its partially discovered function to generate instructions for producing and also encode serine/threonine kinase protein. There are three cluster regions; major (M-bcr) which high in CML patients, minor (m-bcr) 1-2% contribution CML, micro (μ-bcr) very rare case of CML. ABL1 encodes can as tyrosine kinase. translocation ABL...