[3H]-inositol or [3H]-arachidonate was injected intracerebrally into guinea pigs. Labeled nerve endings were incubat?$ with ACh* or CCh, both of which stimulate labeling of PhA and Phi from Pi by > 100% and 70% respectively. The 4 r addition did not affect the in vivo labeled phosphatidyl-[3H]-inositol or [ HI-arachidonyl-diglyceride and -Phi. Enhanced hydrolysis of [3H]-inositol-PhIP and -PhIP...

multifunctional nanomaterials showed graet advantages in drug delivery. folic acid (fa) binding protein, a glycosyl phosphatidyl inositol anchored cell surface receptor for folate, is overexpressed in several human tumors, whereas it is highly restricted in normal tissues. therefore, in this study, fa, polyethylene glycol (peg), and fe3o4 nanoparticles multifunctionalized short multiwall carbon...

The inositol lipids of plant seeds consist of phosphatidyl inositol, the phytoglycolipids, and a previously uncharacterized ceramide-phosphate-polysaccharide. These three species have been separated from each other and from the common glycerophosphatides by a series of simple countercurrent distributions, first as the naturally occurring Ca-Mg salts and subsequently in the Na salt form. The new...

Fatty liver syndrome or hepatic lipidosis (HL) is a condition thought to contribute to an increased incidence of peripartum disease, reduced response to therapy and decreased fertility in dairy cows. This syndrome is characterized by excess triglyceride (TG) accumulation in the liver and apparent decreased hepatic lipoprotein output. In lactating rats, a similar condition results from feeding a...

THE POLYPHOSPHOINOSITIDES, phosphatidyl inositol phosphate and bisphosphate, have been found as trace lipids in yeast (TALWALKAR & LESTER, 1973), protozoans (PALMER, 1973). and mammals (FOLCH, 1949). In mammals, these lipids are thought to be particularly enriched in neural tissue where they have been shown to undergo changes in metabolism with stimulation of the tissue (see MICHELL, 1975; HAWT...

PURPOSE To understand the difference between macular and peripheral regions, tissue samples of human retina, retinal pigment epithelium, and Bruch's membrane/choroid were dissected and analyzed for lipid composition. METHOD To facilitate dissections and enhance the recovery of tissues, eyecups were prefixed for 1 hour in 10% formalin (pH 7). Lipids were extracted from 4-mm trephined punches o...

Effects of ethanol treatment on Leydig cell NADPH-generating enzymes and lipid profiles were studied. Ethanol treatment (3.0 g/kg. b.wt.) twice daily as a 25% (v/v) aqueous solution given to adult Wistar rats reduced the body weight, testis weight and relative weights of the seminal vesicles and ventral prostate. Serum LH and testosterone were also decreased. Similarly, the NADPH-generating enz...