the synthesis of twenty five esters of testosterone (17β -hydroxyandrost- 4-en-3-one) is described. all esters are derivatives of cycloalkycarboxylic acids. some of the esters possess α- , β -and/or & - substitution in the ester side-chain. the work was undertaken in order to evaluate long-acting male antifertility effect of such esters. most of the compounds, especially compound no.1, were fou...

Phosphonate derivatives were prepared using multicomponent reactions of dialkyl acetylenedicarboxylate with 4-hydroxycumarine in the presence of trimethyl or triphenyl phosphite in good yields.

Structure and characterization of [Cu26{2,3,5,6-(Me)4C6H-CH2-PO3}18(μ2-OH)4(μ3-OH)6(μ4-Cl)6(μ-OH2)2(OH2)2(MeCN)4]·6MeCN·15H2O (1) is reported. Complex 1 is the largest discrete molecular homometallic transition metal phosphonate assembly. Remarkably, this gigantic molecular phosphonate has been prepared at room temperature using a normal solution synthetic method.

A set of small nonpeptidic diaryl phosphonate inhibitors was prepared. The phosphonate derivatives were synthesized through Birum-Oleksyszyn reaction followed by reduction of the nitro-group which undergo to Boc-protected guanidine derivatives. After removing of Boc-group by TFAA/DCM afford the guanidine phosphonates.

Vertical scanning interferometry and XPS show the reaction of CaCO3 with the hydration retarder nitrilo-tris-(methylene)phosphonic acid follows a pathway of dissolution of the calcium followed by precipitation of a calcium phosphonate; subsequent surface reorganization/restructuring of the calcium phosphonate exposes the underlying CaCO3 for further hydration.

Homogeneous wild type and feedback-resistant forms of the biosynthetic glycerol-3-phosphate dehydrogenase (NAD+) of Escherichia coli (EC 1.1.1.8) were employed for studies of substrate and inhibitor specificity. The phosphonate analog of dihydroxyacetone-P, 4-hydroxy-3-oxybutyl 1-phosphonate, and glycolaldehyde phosphate proved to be substrates of both enzymes. NADPH, NADH, and nicotinamide h...

Phosphonic acids encompass a common yet chemically diverse class of natural products that often possess potent biological activities. Here we report that, despite the significant structural differences among many of these compounds, their biosynthetic routes contain an unexpected common intermediate, 2-hydroxyethyl-phosphonate, which is synthesized from phosphonoacetaldehyde by a distinct famil...

Influenza remains a major health problem for humans and animals.1 At present, four drugs are approved for influenza prophylaxis and treatment:2 amantadine and rimantadine act as the M2 ion channel blockers, whereas Tamiflu (the phosphate salt of oseltamivir ethyl ester) and Relenza (zanamivir) inhibit the activity of neuraminidase (NA). The NA inhibitors (NAIs) are designed to have (oxa)cyclohe...

Comproportionation reactions between MnCl2 and KMnO4 in the presence of arsonate or phosphonate ligands promote the cation-assisted assembly of high-nuclearity, wheel-shaped or toroidal {Mn8} () and {Mn24} () complexes; the closely corresponding reaction systems provide insights into the complexation behaviour of homologous phosphonate/arsonate ligand species.

 Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catecho...