We report on the optoelectronic properties of GaN$(0001)$ and $(1\bar{1}00)$ surfaces after their functionalization with phosphonic acid derivatives. To analyze possible correlation between acid's electronegativity GaN surface band bending, two types acids, n-octylphosphonic (OPA) 1H,1H,2H,2H-perfluorooctanephosphonic (PFOPA), are grafted oxidized GaN$(1\bar{1}00)$ layers as well nanowires. The...

We recently introduced monoalkyl phosphinic acids as a ligand class for nanocrystal (NC) synthesis. Their metal salts have interesting reactivity differences compared to carboxylates and phosphonates provide cleaner work-up phosphonates. However, little is known about the surface chemistry of NCs with phosphinate ligands. Here, we probe relative binding affinity ligands respect other X-type per...

We previously reported a simple and efficient one-pot procedure for synthesis of 1-hydroxymethylene-1,1-bisphosphonic acids (HMBP). According to this method, we synthesized a series of new aromatic HMBP and investigated structure-activity relationships by evaluating their anti-proliferative activity against A431 human tumor cell line. Our results showed that the introduction of an extra methyle...

Phosphonic acids labeled with beta-emitting radionuclides are promising radiopharmaceutical drugs for palliative therapy of bone metastases. Currently, the possibility using a new osteotropic compound N,N,N’,N’-ethylenediaminetetrakis (methylene phosphonic acid) lutetium-177 (177Lu-EDTMP) is being studied. The aim work to develop compartment mathematical model kinetics 177Lu in body laboratory ...

BACKGROUND Synthetic antisense molecules have an enormous potential for therapeutic applications in humans. The major aim of such strategies is to specifically interfere with gene function, thus modulating cellular pathways according to the therapeutic demands. Among the molecules which can block mRNA function in a sequence specific manner are peptide nucleic acids (PNA). They are highly stable...

Ion-exchange (IX) resins incorporating single functional groups (sulfonic or amino-phosphonic) and two phosphonic) were evaluated for selective recovery of Rare Earth Elements (REEs) from acidic mine waters (AMW). The composition AMW solution, complexing properties the group, acidity investigated as key parameters concentration separation REEs transition elements (TEs). Fe has to be removed ena...

The molecular structure of the stable conformation of phosphonic acid in gas phase has beencomputed by employing complete geometry optimization in Density Functional Theory(DFT) methods. The methods used for calculations are B3LYP, BP86 and B3PW91 that havebeen studied in two series of basis sets: D95** and 6-31+G(d,p) for hydrogen and oxygenatoms; LANL2DZ for phosphorus. Bond lengths and angle...

Short phosphorothioate oligonucleotides have been prepared by refluxing an equimolar mixture of thymidine and triethylammonium phosphite in toluene in the presence of elemental sulfur. Desulfurization and subsequent digestion of the products by P1 nuclease revealed that nearly 80% of the internucleosidic linkages thus formed were of the canonical 3´,5´-type.

The hierarchical assembly of DSCs containing a new heteroleptic copper(I) complex with a phosphonic acid anchoring ligand is described; it is shown that conventional I(-)/I3(-) electrolytes may be replaced by [Co(bpy)3](2+/3+) with no loss in performance.

The reactivity of a (1 1 0) rutile titanium dioxide surface functionalized with neutral, anionic and di-anionic forms dodecyl-phosphonic acid was studied by Density Functional based Tight Binding theory to simulate different pH conditions. Functionalization this is relevant for at least two reasons: a) protect the against external agents (e.g., preventing proliferation bacteria in medical impla...