Many phthalate ester plasticizers are classified as peroxisome proliferators (PP), a large group of industrial and pharmaceutical chemicals. Like PP, exposure to some phthalates increases hepatocyte peroxisome and cellular proliferation, as well as the incidence of hepatocellular adenomas in mice and rats. Most effects of PP are mediated by three nuclear receptors called peroxisome proliferator...

For the quantitative analysis of phthalates in polymers, a thermal desorption (TD)-GC-MS method was compared with solvent extraction (SE)-GC-MS methods which require the long pretreatment procedures using large amount of harmful organic solvents. Calibration curves of TD-GC-MS showed good linearity (r(2)>0.9997) and low method detection limit (<30mg/kg with 9.0% RSD). Quantification results for...

This study investigated the composition of PVC flooring with respect to certain chemical additives, namely phthalate plasticisers and organotins. The study included analysis of five PVC flooring samples that were available for retail in the UK. Samples were found to contain high levels of several organotin compounds, in particular DBT (37.7 to 569 ppm) and TBT (128 to 17,940 ppb). Two phthalate...

Phthalates are a group of industrial chemicals with many commercial uses, such as solvents, additives, and plasticizers. For example, di-(2-ethylhexyl) phthalate (DEHP) is added in varying amounts to certain plastics, such as polyvinyl chloride, to increase their flexibility. In humans, phthalates are metabolized to their respective monoesters, conjugated, and eliminated. However, despite the h...

BACKGROUND A very large proportion of the literature on the endocrine disruptors categorized as anti-androgens deals with phthalates, which are produced in large amounts for use as plastic emollients and additives. In this review, we bring together and analyse work on the effects of phthalates in animals and humans at different stages of their development to assess whether or not their possible...

Phthalates or phthalic acid esters are a class of synthetic chemicals used as plasticizers to soften polyvinyl chloride (PVC) in a wide range of consumer and personal care products. Phthalates are released into the environment and taken up by the general population mainly through ingestion, inhalation, and dermal contact. Phthalates are lipid soluble, have relatively short (less than 24 h) biol...

BACKGROUND Phthalates are metabolized and eliminated in urine within hours after exposure. Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months. OBJECTIVES We examined inter- and intraperson and inter- and intraday variability in the concentrations of monoethyl phthalate...

BACKGROUND Early puberty is a common worldwide problem. Different parameters as genetics, metabolic diseases, obesity, as well as environmental factors may affect the age of puberty. This systematic review aims to survey the related literature on the effects of environmental pollutants and especially organohalogens and phthalates on early puberty. MATERIALS AND METHODS A systematic review of ...

Using a novel and highly selective technique, we measured monoester metabolites of seven commonly used phthalates in urine samples from a reference population of 289 adult humans. This analytical approach allowed us to directly measure the individual phthalate metabolites responsible for the animal reproductive and developmental toxicity while avoiding contamination from the ubiquitous parent c...

One of the most common environmentally relevant groups pollutants are phthalate esters. After decades industrial use, they have become ubiquitous in environment and analytical methods to chemically detect them trace amounts required. In this study, details Proton Transfer Reaction-Mass Spectrometry (PTR-MS) investigations for reactions phthalic acid ten esters with H3O+ as a function reduced el...