This article reviews the physical and chemical constraints of environments on biofilm formation. We provide a perspective on how materials science and engineering can address fundamental questions and unmet technological challenges in this area of microbiology, such as biofilm prevention. Specifically, we discuss three factors that impact the development and organization of bacterial communitie...

Prospects for development of science-intensive industrial sectors demand to carry out new researches of physicochemical processes in extreme conditions and in the design of new materials. The development of predictive modeling at an atomic-molecular level is becoming particularly relevant in recent time. Nowadays such approaches have become possible due to improvements in modern supercomputer t...

Hesperidin nanocrystals was generated by high pressure homogenization. The physicochemical properties of a spray dried hesperidin nanocrystals were investigated including to re-dispersion, crystalline state, kinetic solubility, dissolution velocity. Hesperidin nanosuspension with concentration of 10% (w/v) was dried by a Mini Spray-dryer B-190. Photon correlation spectroscopy (PCS) and laser di...

Plasminogen (profibrinolysin) of high specific activity has been prepared from human sources and converted to plasmin (fibrinolysin) by a variety of means (3, 4). Since these preparations seemed to possess activities of as high an order as any that had yet been produced, it was considered appropriate to examine their purity by physicochemical means. Such investigations do not appear to have bee...

Antiviral interferon activity in any one species can be exhibited by a variety of substances that differ in their physical and chemical properties, but the nature of these differences is not understood. Conditions that can lead to the formation of diverse types of interferons have been outlined. Reasons have been adduced why, for certain purposes, purification of interferons is desirable or eve...

BBB blood-brain barrier BMEC brain microvascular (capillary) endothelial cells CBSA cationic bovine serum albumin CdTe cadmium tellurium CTAB trimethylammonium bromide DRG dorsal root ganglia HSA human serum albumin ip intraperitoneal iv intravenous MWCNT multi-walled carbon nanotube PAMAM poly(amidoamine) PBCA polybutylcyanoacrylate PEG polyethylene glycol PLA poly(lactide) PLGA poly(lactic-co...

It has been known since Wilson's discovery (I) that dissociated ceils of Microd~a come together and form aggregates, which by further transformation develop into new sponges. Similar processes were observed in fresh water and in calcareous sponges (2, 3), and in hydroids and alcyonarians (4, S). Recently one of us (6, 7), in studying the behavior of dissociated cells of Microdona, found that th...

Pharmaceutical design has enabled important advances in the prevention, treatment, and diagnosis of diseases. The use of nanotechnology to optimize the delivery of drugs and diagnostic molecules is increasingly receiving attention due to the enhanced efficiency provided by these systems. Understanding the structures of nanocarriers is crucial in elucidating their physical and chemical propertie...

We describe a series of stringent relationships between abundance, solubility and chaperone usage of proteins. Based on these relationships, we show that the need of Escherichia coli proteins for the chaperonin GroEL can be predicted with 86% accuracy. Furthermore, from the observation that the abundance and solubility of proteins depend on the physicochemical properties of their amino acid seq...

Streptococcal M protein is one of the best characterized anti-phagocytic surface molecules. The protein has a coiled fibrillar structure extending outwards about 600 nm from the streptococcal cell wall. The anti-phagocytic nature of the M protein appears to be related to two properties: ( a ) its ability to bind fibrinogen and the D family of its degradation products, thereby preventing deposit...