نتایج جستجو برای: pigmentation disorder
تعداد نتایج: 606376 فیلتر نتایج به سال:
Dowling-Degos disease (DDD) is an autosomal-dominant disorder of skin pigmentation associated with mutations in keratin 5 (KRT5), protein O-fucosyltransferase 1 (POFUT1), or protein O-glucosyltransferase 1 (POGLUT1). Here, we have identified 6 heterozygous truncating mutations in PSENEN, encoding presenilin enhancer protein 2, in 6 unrelated patients and families with DDD in whom mutations in K...
Rationale: cAMP up-regulates microphthalmia-associated transcription factor subtype M (MITF-M) and tyrosinase (Tyro) in the generation of heavily pigmented melanosomes. Here, we communicate a therapeutic mechanism of hyperpigmented disorder by α-viniferin, an active constituent of Caragana sinica. Methods: We used cAMP-elevated melanocyte cultures or facial hyperpigmented patches for pigmentati...
In this study, the inhibitory effect of corn silk on melanin production was evaluated. This study was performed to investigate the inhibitory effect of corn silk on melanin production in Melan-A cells by measuring melanin production and protein expression. The corn silk extract applied on Melan-A cells at a concentration of 100 ppm decreased melanin production by 37.2% without cytotoxicity. Thi...
Reticulate acropigmentation of Kitamura (RAK) is a rare genetic disorder of cutaneous pigmentation with an autosomal dominant pattern of inheritance and a high penetration rate. The characteristic skin lesions are reticulate, slightly depressed pigmented macules mainly affecting the dorsa of the hands and feet, which first appear before puberty and subsequently expand to the proximal limb and t...
Background. Vitiligo is a pigmentary disorder characterized by depigmented macules due to absence of melanocytes. Increased levels of tumor necrosis factor alpha and interleukin-1 in the epidermis of lesions may play a role in keratinocyte apoptosis and less production of melanogenic cytokines. Tetracyclines reduce production of tumor necrosis factor alpha and interleukin-1. Objective. To evalu...
HIGHLIGHTS • Molecular analysis of aurofusarin biosynthesis in F. culmorum. Mycelial pigmentation depending on gene expression and accumulation. Pigmentation variations growth phase.
Vitiligo is an acquired, chronic condition characterised by depigmentation of the epidermis or destruction/loss melanin. Skin cells (melanocytes) are responsible for producing melanin, substance that gives pigmentation to skin. This review aims provide a comprehensive overview current state knowledge about vitiligo. Although there no specific ethnic group, gender, skin type more prone vitiligo ...
AIM Melanin pigmentation of the gingiva occurs in all ethnicities. Excessive pigmentation is an esthetic concern that has increased awareness about de pigmentation procedures. The purpose of the present study was to correlate skin color and gender with intensity and distribution of gingival melanin pigmentation in a group of South Indians. METHODS 200 male and female non smoking healthy subje...
BACKGROUND To assess the effect of smoking on lip and gingival pigmentation and also to assess the relationship of pigmentation with periodontal parameters. MATERIALS AND METHODS 109 smokers and an equal number of control subjects who were nonsmokers in the age range of 35 - 44 years comprised the study sample. All the participants were assessed for pigmentation on lip and gingiva and a total...
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