We report here the locations of curved DNA in the human erythropoietin receptor gene. A total of 13 DNA bend sites were mapped by circular permutation assays, appearing at an average interval of 651.2+/-214.6 (S.D.) in the 8-kb region. The bend centers in these 13 bend sites were confirmed by oligonucleotide-based assays where most of these centers had bend angles higher than that shown by (AAA...

The blood-brain barrier (BBB) is formed by brain endothelial cells. Many immortalized brain endothelial cell lines have been established; these have been used as in vitro BBB models. The aim of the present study was to assess the paracellular barrier properties of the immortalized mouse brain endothelial cell lines bEND.3, bEND.5 cells, and mouse brain endothelial cell 4 (MBEC4), and those of t...

The present sought to draw a comparison between Model Predictive Control performance and two other controllers named Simple PI and Selective PI in controlling large-scale natural gas transport networks. A nonlinear dynamic model of representative gas pipeline was derived from pipeline governing rules and simulated in SIMULINK® environment of MATLAB®. Control schemes were designed to provide a s...

Submarine pipelines failures lead to oil spills in water and may even lead to explosions with heavy financial and environmental damages. Trawl gear is one of the main factors in the failure of the submarine pipelines. In this paper, sensitivity analysis is performed on influence of height and span length alternations on the response of pipeline against the traction caused by trawling pull-over ...

[1] We perform two-dimensional dynamic models of strike-slip faults with a change in strike (a bend) over multiple earthquake cycles to examine the long-term effects of nonplanar fault geometry. A viscoelastic model (a proxy for off-fault deformation and tectonic loading) is introduced for the interseismic process to avoid pathological stress buildup around the bend. A finite element method wit...

A numerical experiment is carried out to study the suitability of two-dimensional (2D) depth-averaged modeling for bend-flow simulation, in which the geometry of the studied channel is rectangular. Two commonly used 2D depth-averaged models for bend-flow simulation are considered in this study of which the bend-flow model includes the dispersion stress terms by incorporating the assumption of s...