This study aims to the quantitative relationship between molecular structure and biological activity (QSAR) of 7-O-amide hesperetine derivative compounds design new which are more potential as anti-inflammatory. research was theoretically exploratory by using computational chemical methods. The object this 23 7-O-Amide Hesperetine with their anti-inflammatory (IC50) values. data were obtained f...

The asymmetric unit of the title compound, (C(5)H(14)N(2))[ZnCl(4)], consists of a diprotonated 2-methyl-piperazine cation and a tetra-chloridozincate anion. The Zn(II) ion is in a slightly distorted tetra-hedral coordination environment. The six-membered piperazine ring adopts a chair conformation. The crystal structure is stabilized by inter-molecular N-H⋯Cl hydrogen bonds.

A comparative efficacy of piperazine, albendazole and ivermectin against natural infection of Toxocara vitulorum based on faecal egg count in calves was studied. Early recovery was found with piperazine than with either albendazole or ivermectin. However, all the three drugs were effective against ascariasis in cattle calves.

In the title salt, C(6)H(18)N(3) (3+)·3NO(3) (-), the piperazine ring adopts a chair conformation and the ethyl-ammonium group is equatorial relative to the piperazine ring, and in an all-trans conformation. In the crystal, strong charge-assisted N-H⋯O hydrogen bonds link the piperazinediium trications and the nitrate anions into a three-dimensional network.

We present an unusual case of cerebellar ataxia in a 2 year old girl several days after treatment with piperazine citrate for suspected worm infestation. This is the first reported case of delayed onset neurotoxicity following the therapeutic administration of piperazine in a previously well child.

The title salts, C8H13N4 (+)·Cl(-), (I), and C8H13N4 (+)·NO3 (-), (II), contain linked pyridinium-piperazine heterocycles. In both salts, the piperazine ring adopts a chair conformation with protonation at the N atom not linked to the other ring. In the crystal of (I), weak N-H⋯Cl inter-actions are observed, leading to zigzag chains along [100]. In the crystal of (II), both H atoms on the NH2 (...

Deoxypodophyllotoxin (DPT), an active compound isolated from a number of herbs and used in traditional medicine, has been reported to exhibit promising anti‑tumor activity. A newly synthesized derivative, N-(1-oxyl‑4'-demethyl-4-deoxyp odophyllic)-L‑methine-4'-piperazine carbamate (LJ12) may have improved antitumor activity and fewer side effects. The present study assessed the effect of LJ12 o...

An analogue of the DNA binding compound Hoechst 33258, which has the para hydroxyl group altered to be at the meta position, together with the replacement of one benzimidazole group by pyridylimidazole, has been cocrystallized with the dodecanucleotide sequence d(CGCGAATTCGCG)2. The X-ray structure has been determined at 2.2 A resolution and refined to an R factor of 20.1%. The ligand binds in ...