Balc azar, Book, and Sch oning introduced the extended low hierarchy based on the levels of the polynomial-time hierarchy as follows: for k 1, level k of the extended low hierarchy is the set ELP; k = fA j Pk (A) Pk 1(A SAT)g. Allender and Hemachandra and Long and Sheu introduced re nements of the extended low hierarchy based on the and -levels, respectively, of the polynomial-time hierarchy: ...

modified to alter levels of Pk expression.5 The results were significant. P1k cells were protected from R5 and X4 HIV-1 infection and had increased CD4, coreceptor, and Pk expression, while PBMCs with the p phenotype had heightened susceptibility to R5 and X4 HIV-1 infection. Further supporting a role for Pk was that Pk -liposome fusion in Jurkat cells decreased susceptibility to HIV and cells ...

DNA-dependent protein kinase (DNA-PK) is involved in DNA double-strand break (DSB) signalling and repair. We report that DNA-PK is activated by mild hypoxia conditions (0.1-1% O₂) as shown by (1) its autophosphorylation on Ser2056, and (2) its mobilisation from a soluble nucleoplasmic compartment to a less extractable nuclear fraction. The recruitment of DNA-PK was not followed by activation an...

The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteers were enrolled. Peripheral blood was collected, separated and centrifuged; DN...

Human T-cell leukemia virus type-1 is the causative agent for adult T-cell leukemia. Previous research has established that the viral oncoprotein Tax mediates the transformation process by impairing cell cycle control and cellular response to DNA damage. We showed previously that Tax sequesters huChk2 within chromatin and impairs the response to ionizing radiation. Here we demonstrate that DNA-...

Burung puyuh merupakan unggas yang memiliki ukuran tubuh sedang dan relatif tidak bisa terbang seperti burung lainnya. Peningkatan populasi harus diimbangi dengan manajemen pemeliharaan baik, khususnya pada fase pertumbuhan. Alternatif untuk meningkatkan performa pertumbuhan adalah memberikan feed additive dalam ransum, salah satunya umbi bawang dayak. Tujuan penelitian ini mengetahui pengaruh ...

BackgroundTarget-controlled infusion (TCI) systems incorporating pharmacokinetic (PK) or PK-pharmacodynamic (PK-PD) models can be used to facilitate drug administration. Existing were developed using data from select populations, the use of which is, strictly speaking, limited these populations. Recently a propofol PK-PD model was for broad population range. The aim study prospectively validate...

purpose: to compare corneal hysteresis and resistance factor after penetrating keratoplasty (pk) and deep anterior lamellar keratoplasty (dalk) using anwar’s big-bubble technique using the ocular response analyzer. methods: forty-five pk eyes and 23 dalk eyes with keratoconus were compared in terms of corneal hysteresis (ch), corneal resistance factor (crf), goldmann-correlated intraocular pres...

We investigated the relationship between DNA-dependent protein kinase (DNA-PK) activity and radiation sensitivity using 14 esophageal cancer cell lines, TE 1-14. DNA-PK activities differed significantly among the cell lines. The highest DNA-PK activity observed in TE-8 was more than two times higher than the lowest DNA-PK activity observed in TE-5. Significant correlation was observed between D...

BACKGROUND AND OBJECTIVES Red blood cell pyruvate kinase (R-PK) deficiency is the most common glycolytic enzyme defect associated with hereditary non-spherocytic hemolytic anemia. Cases with the most severe deficiency die in the peri- or neonatal period and no specific therapy exists at present. To test whether the targeted overexpression of the normal R-PK gene in erythroid cells could reduce ...