A growing body of evidence indicates that reproductive history influences survival in breast cancer, especially among women diagnosed during or shortly after a pregnancy. However, little is known about the underlying mechanisms. We hypothesized that increasing placental weight, as an indirect marker of exposure to elevated hormone levels during pregnancy, would be associated with reduced surviv...

Many studies have documented that placental development is altered by a variety of environmental factors which alter placental bed blood flow and/or oxygen delivery. One of these is sustained weight-bearing exercise. The purpose of this investigation was to examine the effects of running throughout pregnancy on villous vascular development and cell proliferation by testing the null hypothesis t...

OBJECTIVE To determine the serum leptin levels in Pakistani pregnant subjects at the time of delivery and to ascertain the relationship between serum leptin levels and related variables (weight, body mass index, placental weight, gestational age, parity) at delivery. SETTING Lady Dufferin Hospital, and Ziauddin Hospital Karachi. METHODS Leptin concentration was measured in 110 subjects from...

Maternal malaria is associated with reduced birth weight, which is thought to be effected through placental insufficiency, which leads to intrauterine growth retardation (IUGR). The impact of malaria on preterm delivery is unclear. The effects of placental malaria-related changes on birth weight and gestational age were studied in 1177 mothers (and their newborns) from Tanzania. Evidence of mal...

In a series of matings between congenic strains of mice, differing at the H-2 or H-3 histocompatibility loci, decidual weight and lumbar and caudal lymph-node weight on the 7th day of pregnancy and placental and fetal weight and lumbar and caudal lymph-node weight on the 18th day of pregnancy were measured. There was no evidence that antigenic differences between mother and fetus at these loci ...

The relationships between genotype and placental traits, parity and litter weight (LW), and factors affecting these characteristics were investigated in this study. In total, 112 ewes (Romanov crossbred and local breeds) were utilized. One-way ANOVA was used for statistical comparison, and a Pearson correlation was used to determine the relationships between the variables. Significant differenc...

This study was designed to evaluate the degree of placenta share discordance in relation to the betamethasone-induced return of positive end-diastolic flow in monochorionic twin pregnancies with selective intrauterine growth restriction (sIUGR) and abnormal umbilical artery Doppler. Monochorionic twins with sIUGR was defined as one twin having an estimated fetal weight below the 10th percentile...

A prospective study has been carried out of placental lactogen levels in pregnancy complicated by diabetes mellitus. The levels were higher than those in normal pregnant subjects; the higher levels were related to increased placental and fetal weight but more closely to the former; and lower levels were found when there was clinical evidence of placental dysfunction. Those patients requiring th...