Background: Light chain (AL) amyloidosis is a plasma cell disorder characterized by abnormal fibrillary light deposition causing cardiac, renal, hepatic, gastrointestinal and peripheral nervous system dysfunction. Muscle disease occurs in 1.5% of individuals progressive proximal weakness thus far considered untreatable. Methods: We reviewed two cases AL associated myopathy at our institution wh...

Background: COVID-19 pandemic is a global concern. In this study we suggest using a novel three-dimensional treatment mainly based upon immune system modulation to revolve the virus chaos, regarding to the cytokine storm introduced as the main character of COVID-19 infection scenario. Case Presentation: A young man infected by 2019-nCoVwho suffered from respiratory arrest and loss of conscious...

BACKGROUND Outcome data in paediatrics regarding the use of plasmapheresis for immunological kidney disease are scarce. OBJECTIVES We aimed to evaluate the role of plasmapheresis in children presenting with severe renal impairment secondary to immunological kidney diseases. METHODS A retrospective chart review of children admitted between January 2009 and August 2013 to the Paediatric Nephr...

of high-dose steroids and an immunosuppressive agent. Therapy with intravenous cyclophosphamide is the agent best studied for SLE. Intravenous immunoglobulinhasalso proven tobebeneficial in selectedpatients.Theroleofmethotrexate in the treatment of SLE remains unproven, but itssafetyrecordmakes itanattractivealternative,especially for thecontrol of some steroid-refractory manifestations of SLE....

Thrombotic thrombocytopenic purpura (TTP) is a haematological disorder which affects the arterioles and capillaries of multiple organs. We reported three cases of TTP successfully treated with low-dosage rituximab combined with plasmpheresis. All three cases were diagnosed according to the diagnostic criteria of TTP. A weekly doses of 100 mg rituximab was applied for four weeks of presentation ...

Potential thoracic organ transplantation recipients who have positive cytotoxic antibody screens as quantified panel reactive antibodies (PRA) are at risk for immediate or long-term immunologic events that may affect the donor organ. The patient population at risk includes those who are supported with cardiac assist devices, multiparous women, and individuals receiving numerous homologous blood...

Objective: To determine the frequency and type of adverse effects associated with plasmapheresis among patients neurological disorders at a tertiary care hospital in Pakistan.
 Study Design: Prospective longitudinal study.
 Place Duration Study: Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jan to Jun 2019.
 Methodology: The sample population comprised 150 various req...

Three patients with cryoglobulinemia have been treated with automated plasma exchange procedures in which the replacement fluid was autologous plasma, obtained at a previous plasmapheresis and incubated in the cold to precipitate abnormal protein. All three responded with a reduction in cryoglobulin level and an improvement in clinical manifestations of cryoglobulinemia. The cost of treatment w...