To prove that the peptidic HIV-1 fusion inhibitors containing the pocket-binding domain (PBD) mainly target the hydrophobic pocket in the gp41 N-terminal heptad repeat (NHR), we constructed pseudoviruses by replacement of Q64 in the gp41 pocket region with Ala (Q64A) or Leu (Q64L). These viruses were highly resistant to C34 and CP32M containing the PBD, while they were susceptible to T20 (enfuv...

The 2007‐2009 U.S. recession led to large increases in the potential duration of unemployment benefits (PBD), which could decrease job search effort. I measure search effort by job applications on the popular website Careerbuilder.com. Using an event study and nonlinearities in the relationship between PBD and the unemployment rate, I find that a one‐week increase in PBD decreases state‐le...

We present studies of the photoexcited quasiparticle dynamics in MgB2 where, using femtosecond optical techniques, Cooper pair-breaking dynamics (PBD) have been temporally resolved for the first time. The PBD are strongly temperature and photoexcitation intensity dependent. Analysis of the PBD using the Rothwarf-Taylor equations suggests that the anomalous PBD arises from the fact that in MgB2 ...

“Programming-by-Demonstration” (PbD) is a very intuitive and efficient means for programming robots for a specific task. One approach for PbD uses manual guided robots to show the task the robot has to perform. Even though manual guidance is a lot more intuitive than traditional programming, first experiences showed that there is still training needed to make full use of such a system. This pap...

OBJECTIVE The pediatric bipolar disorder profile of the Child Behavior Checklist (CBCL-PBD), a parent-completed measure that avoids clinician ideological bias, has proven useful in differentiating patients with attention-deficit/hyperactivity disorder (ADHD). We used CBCL-PBD profiles to distinguish patterns of comorbidity and to search for quantitative trait loci in a genomewide scan in a samp...

AIMS AND OBJECTIVE To study the role of myoepithelial (ME) cells in distinguishing benign, proliferative breast diseases (PBD) and frank malignant breast lesions. MATERIALS AND METHODS In this study, histology proven 71 cases of fine needle aspiration cytology (FNAC) of palpable breast lesions were selected. There were 30 invasive carcinomas (24 infiltrating duct carcinoma and 6 infiltrating ...

Perihilar cholangiocarcinoma (pCC, also known as a Klatskin tumor) is the most common type of cholangiocarcinoma (CC). Preoperative biliary drainage (PBD) is indicated for pCC patients with acute cholangitis or patients who need portal vein embolization (PVE). However, the routine performance of PBD in other patients with pCC is still controversial. The current study retrospectively examined pa...

Pigmented tumors have similar clinical features that overlap and hamper diagnosis. Dermoscopy increases the diagnostic accuracy of doubtful melanocytic lesions and has been used as a noninvasive tool in the detection of pigmented lesions (PLs) like melanoma, basal cell carcinoma, and pigmented Bowen's disease (pBD). Our objective was to show the dermoscopic features of 2 cases of pBD and compar...

BACKGROUND The transition to the Next Accreditation System is well underway, and a shift toward competency-based assessment in the form of milestones is now the standard. A significant effort has been completed by the Plastic Surgery Milestones Working Group to develop specific milestones and assessment tools for plastic surgery training. METHODS The history of the development toward competen...