Structure analysis of the cytochrome bc1 complex in the presence and absence of Qp quinol analog inhibitors implied that a large amplitude motion of the Rieske iron-sulfur protein (ISP) is required to mediate electron transfer from ubiquinol to cytochrome c1. Studies of the functional consequences of mutagenesis of an 8-residue ISP "hinge" region in the bc1 complex showed it to be sensitive to ...

Support vector machines are one of the most popular machine learning methods for classification. Despite its great success, the SVM was originally designed for binary classification. Extensions to the multicategory case are important for general classification problems. In this article, we propose a new class of multicategory hinge loss functions, namely reinforced hinge loss functions. Both th...

This paper examines analytically the design criteria for composite retrofit of reinforced concrete (RC) columns with a short lap splice length steel rebars inside critical region. The advanced potential pseudo-dynamic three-dimensional (3D) finite element (FE) modelling is utilized to investigate parameters required carbon fiber-reinforced polymer (FRP) jacketing RC rectangular cross-section ba...

Three-dimensional transient deformations of clamped flat and doubly curved polycarbonate (PC) panels impacted by a rigid smooth hemispherical-nosed circular cylinder have been numerically studied by the finite-element (FE) method to delineate effects of the panel radius of curvature to its thickness ratio on their penetration resistance. The PC is modeled as thermoelastoviscoplastic with the ef...

We investigated the evolution of the response of human, chicken, alligator and frog glucocorticoid receptors (GRs) to dexamethasone, cortisol, cortisone, corticosterone, 11-deoxycorticosterone, 11-deoxycortisol and aldosterone. We find significant differences among these vertebrates in the transcriptional activation of their full length GRs by these steroids, indicating that there were changes ...

Abstract The paper shows the results of an experimental campaign aimed at investigating cyclic behavior a column-to-foundation joint for precast concrete elements. tested connection is realized adopting corrugated steel ducts embedded into foundation, in which column protruding rebars are anchored by grouting high performance mortar. program consists testing six full-scale reinforced square-sec...

Recent earthquakes severely damaged short columns due to high lateral stiffness and low ductility. Some conditions, such as reductions in the heights of some compared others on same floor, deep beams, partially buried basements, non-structural walls, cause column effects. The prominent characteristics engineered cementitious composites (ECCs) reinforced with polyvinyl alcohol (PVA) fibers – inc...