Objective: At present, growth factor-containing products such as enamel matrix derivatives, recombinant bone morphogenetic protein (rh-BMP), recombinant platelet derived growth factor and platelet rich plasma (PRP) have gained increasing attention. PRP is an autologous source of platelet growth factors used to enhance healing of soft and hard tissues. PRP has gained popularity due to its auto...

  The clinical use of PRP therapy in the practical setting of orthopaedic fields is increasing partly because of the accessibility of devices that are used in outpatient preparation and delivery. Another reason is the strong advertisement of PRP procedures as the ultimate treatment and novel technology for knee problems by a few orthopaedic surgeons based on claims of abundant scientific eviden...

Background  Many biomaterials are used during the open sinus lift surgery, beneath the elevated scheniderian membrane and maxillary sinus bony floor but the search for Ideal material continues. Methods  In the maxillary posterior atrophic ridges with the bone height less than four millimeters the open sinus lift surgery performed. The autologous Platelet-rich plasma (PRF) was used as the sol...

BACKGROUND The purpose of this study was to create biomaterial scaffolds like platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) containing stromal cell-derived factor-1 (SDF1) as a chemokine to induce hyaline cartilage regeneration of rabbit knee in a full thickness defect. METHODS We created a full thickness defect in the trochlear groove of thirty-six bilateral knees of eighteen mat...

conclusions prp dressing could significantly decrease the depth and surface area of dfus in a three-week period. background some of the studies confirmed the effectiveness of platelet rich plasma (prp) in the treatment of diabetic foot ulcers (dfu). however, these studies had small sample size and used different methods such as prp gel or prp injections. the results are also contraversial. obje...

background:the aim of this study is to find out the spatial and temporal expression of tgf-b1 during the tendon healing, after application of platelet rich plasma (prp). methods: a patellar tendon defect model in rabbits was used for this purpose. 48 skeletally mature new zealand white rabbits, weighing 3.5 kg, were used for this study. equal numbers of animals from both groups were sacrificed ...

objectives:  the efficacy of adding platelet-rich plasma (prp) to demineralized freeze-dried bone allograft (dfdba) in order to improve the clinical and radiographic results obtained in treatment of deep periodontal intrabony defects has yet to be fully elucidated. materials ­and methods: this double blind, split-mouth randomized controlled clinical trial was conducted on 12 patients with two c...

The aim of this study was to assess a novel approach to treating severe knee osteoarthritis by targeting synovial membrane, superficial articular cartilage, synovial fluid, and subchondral bone by combining intra-articular injections and intraosseous infiltrations of platelet rich plasma. We explored a new strategy consisting of intraosseous infiltrations of platelet rich plasma into the subcho...

Platelet-rich fibrin, developed in France by Choukroun et al., is a second generation platelet concentrate widely used to accelerate soft and hard tissue healing. It is a strictly autologous fibrin matrix containing a large quantity of platelet and leukocyte cytokines. It has also been shown to stimulate the growth of osteoblasts and periodontal ligament cells, both of which are significant for...

Pseudoarthrosis, or nonunion, of the long bones is a challenging medical condition for orthopedic surgeons to treat. Therefore, healing enhancer materials are commonly used. The authors investigated whether platelet-rich fibrin accelerates long bone healing by comparing radiological and histological findings in a rat model of open femoral fracture. Platelet-rich fibrin is a current biomaterial ...