Dichloro-1,2-diaminocyclohexane (DACH):platinum(ll), the pro totype DACH:platinum complex, had good antitumor activity, was not cross-resistant with c/'s-dichlorodiammineplatinum(ll) (DDP), but was, unfortunately, virtually insoluble in water and was, therefore, not evaluated clinically. This paper summarizes some of the chemical and biological attributes of a series of c/'sbisascorbato-DACH:pl...

Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase.

DNA-alkylating agents that are platinum complexes induce apoptotic responses and have wide application in cancer therapy. The potential for platinum compounds to modulate signal transduction events that contribute to their therapeutic outcome has not been extensively examined. Among the signal transducer and activator of transcription (STAT) proteins, Stat3 activity is frequently up-regulated i...

Platinum(II) anticancer drugs are among the most effective and often used chemotherapeutic drugs. In recent years, there has been increasing interest in exploiting inert platinum(IV) scaffolds as a prodrug strategy to mitigate the limitations of platinum(II) anticancer complexes. In this prodrug strategy, the axial ligands are released concomitantly upon intracellular reduction to the active pl...

A novel series of ammine/cyclohexylamine platinum(II) complexes with 1-(substituted benzyl) azetidine-3, 3-dicarboxylates as leaving groups have been synthesized and characterized. All complexes were characterized by elemental analysis, IR, (1)H NMR, and ESI-MS spectra. The in vitro antiproliferative activities of the platinum-based compounds have been investigated against several human cancer ...

The oxidative addition of cyclic ditelluride 1-oxa-5,6-ditelluraspirooctane, Te(2)C(5)H(8)O, to bis(triphenylphosphine)(norbornene)platinum(0), [Pt(PPh(3))(2)(eta(2)-nb)], and to [1,8-bis(diphenylphosphino)naphthalene](norbornene)platinum(0), [Pt(dppn)(eta(2)-nb)], lead to the formation of dinuclear and mononuclear tellurolato platinum(ii) complexes, respectively, as a consequence of Te-Te bond...

In the last few years, interest in platinum drugs has increased. Successful treatment depends to a large extent on complex therapy and early diagnosis, which determines great importance of knowledge risk groups, clinical symptoms, targeted use diagnostic methods with biomarkers, biopsy imaging for detection malignant process. Today, mono-target strategy is being replaced by poly-target strategy...

The diverse anticancer utility of cisplatin has stimulated significant interest in the development of additional platinum-based therapies, resulting in several analogues receiving clinical approval worldwide. However, due to structural and mechanistic similarities, the effectiveness of platinum-based therapies is countered by severe side-effects, narrow spectrum of activity and the development ...

Inhalation of platinum, as soluble salts, is known to cause respiratory distress and severe dermatitis in workers. Platinum coordination complexes are widely used in the treatment of a variety of solid tumors. However, the clinical use of cisplatin (CDDP) (the most useful agent) is limited by the development of nephrotoxicity. High dose accidental exposure to soluble platinum in platinum refine...