sive study because of its role in (i) the packing of aromatic molecules in the crystalline state, (ii) base-stacking interactions of DNA, (iii) three-dimensional structures of proteins, (iv) molecular recognition of pharmaceuticals by biological receptors or enzymes, and (v) template-directed synthesis. Ternary complexes of platinum(II) or palladium(II) containing 2,2 -bipyridine (bpy) or 1,10-...

A range of androgen conjugates with non-conventional platinum(II) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(II) co...

An important feature of biological systems to achieve complexity and precision is the involvement of multiple components where each component plays its own role and collaborates with other components. Mimicking this, we report living supramolecular polymerization achieved by collaborative assembly of two structurally dissimilar components, that is, platinum(II) complexes and poly(ethylene glyco...

Platinum-metal oxidation catalysts are to be introduced in exhaust systems of many 1975 model-year automobiles in the U.S. to meet Clean Air Act standards. Small quantities of finely divided catalyst have been found issuing from prototype systems; platinum and palladium compounds may be found also. Although platinum exhibits a remarkable resistance to oxidation and chemical attack, it reacts ch...

The electrodeposition of gold and platinum complexes at the electrochemical interfaces on the coronene-modified Au(111) surface was investigated. Scanning tunneling microscopy revealed the spontaneous deposition of gold and platinum complexes, suggesting that the coronene adlayer plays an important role in the electroreduction of these complexes.

Nuclear DNA is the target responsible for anticancer activity of platinum anticancer drugs. Their activity is mediated by altered signals related to programmed cell death and the activation of various signaling pathways. An example is activation of nuclear factor kappaB (NF-κB). Binding of NF-κB proteins to their consensus sequences in DNA (κB sites) is the key biochemical activity responsible ...