Partial least squares (PLS) is an efficient statistical regression technique that is highly suited for the analysis of genomic and proteomic data. In this article, we review both the theory underlying PLS as well as a host of bioinformatics applications of PLS. In particular, we provide a systematic comparison of the PLS approaches currently employed, and discuss analysis problems as diverse as...

Transcriptomic and peptidomic analysis of skin secretions from the Painted-belly leaf frog Phyllomedusa sauvagii led to the identification of 5 novel phylloseptins (PLS-S2 to -S6) and also of phylloseptin-1 (PSN-1, here renamed PLS-S1), the only member of this family previously isolated in this frog. Synthesis and characterization of these phylloseptins revealed differences in their antimicrobi...

Most bacterial glycoproteins identified to date are virulence factors of pathogenic bacteria, i.e. adhesins and invasins. However, the impact of protein glycosylation on the major human pathogen Staphylococcus aureus remains incompletely understood. To study protein glycosylation in staphylococci, we analyzed lysostaphin lysates of methicillin-resistant Staphylococcus aureus (MRSA) strains by S...

Primary lateral sclerosis (PLS) is a diagnosis of exclusion in patients with progressive spinobulbar spasticity and could be part of the clinical spectrum of ALS. Unlike ALS, which is familial in 5 to 10% of the cases, PLS has been described as a sporadic disorder in adults. The authors report two patients with PLS from unrelated SOD1-negative familial ALS families. These observations provide f...

Partial Least Squares (PLS) is a widely used technique in chemometrics, especially in the case where the number of independent variables is significantly larger than the number of data points. There are many articles on PLS [HTF01, GK86] but the mathematical details of PLS do not always come out clearly in these treatments. This paper is an attempt to describe PLS in precise and simple mathemat...

The p21-activated kinases (PAKs) play essential roles in diverse cellular processes and are required for cell proliferation, apoptosis, polarity establishment, migration, and cell shape changes. Here, we have identified a novel function for the group I PAKs in cell-cell fusion. We show that the two Drosophila group I PAKs, DPak3 and DPak1, have partially redundant functions in myoblast fusion i...

Nicotine and a variety of other drugs and toxins are metabolized by cytochrome P450 (CYP) 2A6. The aim of the present study was to build a quantitative structure-activity relationship (QSAR) model to predict the activities of nicotine analogues on CYP2A6. Kernel partial least squares (K-PLS) regression was employed with the electro-topological descriptors to build the computational models. Both...

This paper addresses the problem of online quality prediction in processes with multiple operating modes. The paper proposes a new method called mixture of partial least squares regression (Mix-PLS), where the solution of the mixture of experts regression is performed using the partial least squares (PLS) algorithm. The PLS is used to tune the model experts and the gate parameters. The solution...

Projection to latent structures or partial least squares (PLS) produces output-supervised decomposition on inputX, while principal component analysis (PCA) produces unsupervised decomposition of inputX. In this paper, the effect of outputYon theX-space decomposition in PLS is analyzed andgeometric properties of the PLS structure are revealed. Several PLS algorithms are compared in a geometric w...