نتایج جستجو برای: pluripotency specific
تعداد نتایج: 1040520 فیلتر نتایج به سال:
Many types of epigenetic profiling have been used to classify stem cells, stages of cellular differentiation, and cancer subtypes. Existing methods focus on local chromatin features such as DNA methylation and histone modifications that require extensive analysis for genome-wide coverage. Replication timing has emerged as a highly stable cell type-specific epigenetic feature that is regulated a...
The cells can divide and differentiate into several types of in an organism. It is not able to as the extraembryonic tissues, which are termed ‘pluripotent cells’. transcription factors such as, SOX-2, C-MYC, OCT-4 KLF-4 involved maintenance pluripotency. Pluripotent stem (PSCs) self-renewal cells, may be either induced pluripotent (iPSCs) or embryonic (ESCs). used treatment diseases like cance...
OBJECTIVE Every cell type is characterized by a specific transcriptional profile together with a unique epigenetic landscape. Reprogramming factors such as Oct4, Klf4, Sox2 and c-Myc enable somatic cells to change their transcriptional profile and convert them to pluripotent cells. Small molecules such as BIX-01294, Bay K8644, RG-108 and valproic acid (VPA) are reported as effective molecules f...
BACKGROUND Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells. Recently, selection of fully reprogrammed cells was achieved based on colony morphology reminiscent of embryonic stem (ES) cells. The maintenance of pluripotency was analysed. METHODOLOGY/PRINCIPAL FINDINGS Clonal murine iPS cell line TiB7-4, which was derived from adult fibroblasts, was analysed for maint...
BACKGROUND REST is abundantly expressed in mouse embryonic stem cells (ESCs). Many genome-wide analyses have found REST to be an integral part of the ESC pluripotency network. However, experimental systems have produced contradictory findings: (1) REST is required for the maintenance of ESC pluripotency and loss of REST causes increased expression of differentiation markers, (2) REST is not req...
The reprogramming factors that induce pluripotency have been identified primarily from embryonic stem cell (ESC)-enriched, pluripotency-associated factors. Here, we report that, during mouse somatic cell reprogramming, pluripotency can be induced with lineage specifiers that are pluripotency rivals to suppress ESC identity, most of which are not enriched in ESCs. We found that OCT4 and SOX2, th...
Cells with the unique capacity of self-renewal and potency are called as stem cells.Stem cells undifferentiated pluripotent that can differentiate into specialized a more specific function. Defects ofOral maxillofacial region could be most possibly cured by therapy cells. Through search in PubMed, Google, Scopus Medline, many original research papers were found keywords such cells, pluripotency...
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