objective(s):despite of wide range applications of polymeric nanoparticles in protein delivery, there are some problems for the field of protein entrapment, initial burst and controlled release profile.   materials and methods: in this study, we investigated the influence of some changes in plga nanoparticles formulation to improve the initial and controlled release profile. selected parameters ...

Here, we produce poly(lactide-co-glycolide) (PLGA) based microparticles with varying morphologies, and temperature responsive properties utilizing a Pluronic F127/dextran aqueous two-phase system (ATPS) assisted self-assembly. The PLGA polymer, when emulsified in Pluronic F127/dextran ATPS, forms unique microparticle structures due to ATPS guided-self assembly. Depending on the PLGA concentrati...

A large number of studies have shown that bufalin can have a significant antitumor effect in a variety of tumors. However, because of toxicity, insolubility in water, fast metabolism, short half-life, and other shortcomings, its application is limited in cancer therapy. In this study, we explored the anti-metastatic role of bufalin-loaded pluronic polyetherimide nanoparticles on HCT116 colon ca...

An anthracene oil-based pitch, supplied by Industrial Química del Nalón, S.A was used as carbon matrix precursor (softening point of 112oC; elemental analysis: C: 93.6 %, H: 4.4 %, N, 1.0 %, S, 0.5% and O, 0.5%). The iron oxide nanoparticles were obtained following different procedures: (i) toluene reflux of Fe(CO)5 with Pluronic P127 in the presence of H2 [1]; (ii) treatment of a mixture of Fe...

Our previous studies have demonstrated that surfaceactive copolymers of Pluronic® surfactants and tertiary amino polycations such as poly (2-dimethylaminoethyl methacrylate) (PDMA) possess an enhanced DNA transfection efficiency compared to PDMA homopolymers. In order to understand the mechanism of such action, we conducted model studies of the interaction of polymer with phospholipid vesicles ...

INTRODUCTION: Curcuminoids and Oleic acid, reported in the literature as antioxidant antitumor agents, were combined nanoemulsion, using Pluronic F127 a stabilizer.
 METHODS: The main objective is to investigate its cytotoxic activity against cancer cells.
 RESULTS AND DISCUSSION: nanoemulsion show values of particle size (251.4 ± 4.6 nm), zeta potential (-34.8 1.0 mV), pH (4.8) class...

Control of structure and morphology of Pt-based nanomaterials is of great importance for electrochemical energy conversions. In this work, we report an efficient one-step synthesis of bimetallic porous AuPt nanoparticles (PAuPt NPs) in an aqueous solution. The proposed synthesis is performed by a simple stirring treatment of an aqueous reactive mixture including K2PtCl4, HAuCl4, Pluronic F127 a...

Demineralized bone matrix (DBM) is widely used for bone regeneration. Since DBM is prepared in powder form its handling properties are not optimal and limit the clinical use of this material. Various synthetic and biological carriers have been used to enhance the DBM handling. In this study we evaluated the effect of gamma irradiation on the physical-chemical properties of Pluronic and on bone ...