In the last decade, interest in physical organogels has grown rapidly with the discovery and synthesis of a very large number of diverse molecules, which can gel organic solvents at low concentrations. The gelator molecules immobilise large volumes of liquid following their self-assembly into a variety of aggregates such as rods, tubules, fibres and platelets. The many interesting properties of...

A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined nano-micelles in aqueous solution because of their obvious amphiphilic property and low critical ...

ABSTRACT The objective of this study was to develop a novel subgingival sustained-release system for local delivery bioactive minocycline hydrochloride periodontal disease treatment in dogs. incorporated the Minocycline hydrochloride-Calcium-Dextran sulfate sodium into thermoresponsive Pluronic F127 hydrogel. sustained release from up 10 days and kinetics fit power law model. medium had signifi...