Summary Introduction. Phleum pratense (Timothy grass) is the most frequent cause of grass allergy in Europe. Molecular-based allergy diagnostics have been recently introduced in the clinical practice, allowing to define and characterize exactly the sensitization profile. Aim of the study. The present study was aimed to investigate the possible relationships between Graminaceae pollen data and t...

Allergen-specific IgE is linked to asthma pathogenesis, but the underlying mechanisms of IgE production in response to allergen exposure are poorly understood. In this article, we show that B cell-intrinsic MyD88 is essential for IgE/IgG1 production evoked by ragweed pollen instilled into lungs. MyD88-deficient mice showed defective IgE/IgG1 production and germinal center responses to lung inst...

Proteomic analysis was used to generate a map of Populus deltoides CL. "2KEN8" mature pollen proteins. By applying 2-D electrophoresis, we resolved 403 protein spots from mature pollen. Using the matrix-assisted laser desorption/ionization time time-of-flight/time-of-flight tandem mass spectrometry method, we identified 178 distinct proteins from 218 protein spots expressed in mature pollen. Mo...

BACKGROUND Asthma exacerbation is the most common cause of hospital admission in children. A study was undertaken to investigate the importance of allergen exposure in sensitised individuals in combination with viral infections and other potentially modifiable risk factors precipitating asthma hospital admission in children. METHODS Eighty four children aged 3-17 years admitted to hospital ov...

BACKGROUND The cross-reactive allergen responsible for the so called "mugwort-celery-spice-syndrome", a pollen-food allergy that occurs in a minority of mugwort pollen-allergic patients, is still undefined. OBJECTIVE To identify the allergen responsible for the cross-reactivity between mugwort pollen and plant-derived foods. METHODS The serum from one index patient with both fennel and mugw...

BACKGROUND Recent studies in a few industries have shown that the likelihood of IgE-mediated sensitization increases with increasing exposure. The shape of the exposure-response relationships and modification by age, sex, and smoking habit has hardly been studied. OBJECTIVE The purpose of this study was to determine exposure sensitization relationships for rat sensitization and to evaluate th...

BACKGROUND Among birch pollen allergic patients up to 70% develop allergic reactions to Bet v 1-homologue food allergens such as Api g 1 (celery) or Dau c 1 (carrot), termed as birch pollen-related food allergy. In most cases, specific immunotherapy with birch pollen extracts does not reduce allergic symptoms to the homologue food allergens. We therefore genetically engineered a multi-allergen ...

BACKGROUND The adaptive immunity underlying allergy comprises two components, the allergen-specific antibody (i.e. IgE, IgG) and the T-cell response. These two components are responsible for different disease manifestations and can be targeted by different therapeutic approaches. Here, we investigated the association of allergen-specific antibody and T- as well as B-cell responses in pollen-all...

Iran is the main producer of Saffron in the world and a great number of Khorasan (the largest province of Iran) are involved in growing this plant. Recently, saffron pollen has found great importance due to inducing allergic reactions. In this study, the prevalence and clinical symptoms of saffron pollen allergy and specific IgE level in saffron workers have been studied. For this purpose, 167 ...

Methods We evaluated subjects from Southern Romania, a Central European region with temperate continental climate with submediterranean and humid subtropical influences, where sensitization to Betulaceae pollen is less important in pollinosis compared with that to grass or weed pollen. We selected adult patients from the region of sylvosteppe with low density forests dominated by deciduous spec...