Streptomyces griseoaurantiacus M045, isolated from marine sediment, produces manumycin and chinikomycin antibiotics. Here we present a high-quality draft genome sequence of S. griseoaurantiacus M045, the first marine Streptomyces species to be sequenced and annotated. The genome encodes several gene clusters for biosynthesis of secondary metabolites and has provided insight into genomic islands...

In the title compound, C(12)H(13)N(3)O(2), the dihedral angle between the pyrazole and benzene rings is 50.0 (3)°. In the crystal, mol-ecules are linked by inter-molecular N-H⋯O hydrogen bonds to form a three-dimensional network. Two weak C-H⋯π inter-actions reinforce the crystal packing.

In the title compound, C(18)H(19)N(3)O(3)S, the phenyl ring and the pyrazole ring are twisted with respect to each other by an angle of 49.11 (7)°. The C-N-S-C torsion angle is -122.5 (2)°. The methyl group bonded to the N atom of the pyrazole ring has a large deviation from the mean ring plane of 0.603 (3) Å. One inter-molecular N-H⋯O and two non-classical inter-molecular C-H⋯O hydrogen bonds ...

We describe a gas-liquid chromatographic (GC) method for determination of oxybuprocaine, and a gas chromatographic-mass spectrometric (GC-MS) method for simultaneous determination of four of its nine metabolites in urine. We used an Extrelut column to simply and rapidly extract oxybuprocaine and its metabolites from urine. For the GC-MS analyses, we monitored the characteristic fragment ions at...

A new in-situ NMR strategy (termed CLASSIC NMR) for mapping the evolution of crystallization processes is reported, involving simultaneous measurement of both liquid-state and solid-state NMR spectra as a function of time. This combined strategy allows complementary information to be obtained on the evolution of both the solid and liquid phases during the crystallization process. In particular,...

Two p-aminobenzoic acid-resistant mutants of the Madrid E strain of Rickettsia prowazekii, pr and prr have been described in previous publications (Weiss et al., 1957; 1959). It has been shown that certain properties, such as antigenic specificity, infectivity, and virulence for the chick embryo and cotton rat, have not changed in these strains. However, when the study was extended to susceptib...

Abstract Disinfecting activity test of four diphenyltin(IV) benzoate derivative compounds has been carried out. The investigated were diphenyltin (IV) di 4 aminobenzoate (DPDA) ( 2 ), chlorobenzoate (DPDC) 3 di-4-hydroxybenzoate (DPDH) and di-4-nitrobenzoate (DPDN) 5 they prepared by reacting oxide (DPO) 1 ) with benzoic acid derivatives 4-aminobenzoic (4-HABz), 4-chlorobenzoic (4-HCBz), 4-hydr...