background: the aim of this study was to determine the prevalence and risk factors of the sensory neuropathy in type 2 diabetic patients referring to yazd diabetes research center. neuropathy is one of the most common complications of both type 1 and type 2 diabetes melli-tus. material and methods: this is a cross-sectional study on 2350 diabetic patients (1071 male, 1279 female) referred to ya...

Evidence for important roles of the highly reactive oxidant peroxynitrite in diabetic complications is emerging. We evaluated the role of peroxynitrite in early peripheral neuropathy and vascular dysfunction in STZ-diabetic rats. In the first dose-finding study, control and STZ-diabetic rats were maintained with or without the potent peroxynitrite decomposition catalyst Fe(III)tetrakis-2-(N-tri...

Background and aim Damage to small nociceptive fibres may contribute painful diabetic neuropathy. We aimed compare large nerve fibre measurements together with skin biopsy corneal confocal microscopy in patients type 1 diabetes or painless Methods have assessed the McGill pain questionnaire, neuropathy disability score, vibration perception threshold, warm cold sensation thresholds, electrophys...

OBJECTIVE The aim of this study is to determine the mode of presentation, medical and surgical treatment in diabetic foot. METHODS Medical notes of 34 diabetic patients admitted to King Abdulaziz University Hospital in Jeddah from June 1997 to June 1999 with diabetic foot were studied retrospectively. Collection of demographic data, mode of presentation, investigations, medical treatment (ant...

pharmacokinetic/pharmacodynamic (pk/pd) relationships describe the quantitative relationships between the drug-induced effects and the concurrent corresponding drug concentrations in an individual. since a long time, rough qualitative relationships have been described between neurological presentation and plasma ethanol concentration in acute ethanol ingestion. however, to date, precise quantit...

Neural disturbances are observed in the peripheral and central nervous systems of patients with insulin-dependent diabetes mellitus (IDDM) and non-IDDM (NIDDM). Insulin-like growth factors (IGFs) are neurotrophic growth factors that can support nerve regeneration and neuronal survival in the types of neurons known to be afflicted in diabetes. We tested the hypotheses that IGF gene expression is...

Neuropathy target esterase (NTE) is a membrane protein found in human neurons and other cells, including lymphocytes. Binding of certain organophosphorus (OP) compounds to NTE is believed to cause OP-induced delayed neuropathy (OPIDN), a type of paralysis for which there is no effective treatment. Mutations in NTE have also been linked with serious neurological diseases, such as motor neuron di...

objective(s):the neuroprotective effect offruit aqueous extract of ziziphus jujuba lam on glucose-induced neurotoxicity in pc12 cells as an appropriate in vitro model of diabetic neuropathy was investigated. materials and methods: cell viability was determined by the mtt assay. cellular reactive oxygen species (ros) generation was measured by dcfh-da analysis. cleaved caspase-3, a biochemical p...