Polycyclic alkaloids bearing all-carbon quaternary centers possess a diversity of biological activities and are challenging targets in natural product synthesis. The development of a general and asymmetric catalytic method applicable to the efficient syntheses of a series of complex polycyclic alkaloids remains highly desirable in synthetic chemistry. Herein we describe an efficient palladium-c...

Key words polycyclic aromatic hydrocarbons - corannulenes dibenzobistetracene

Ciguatoxins are a family of marine toxins composed of transfused polycyclic ethers. It has not yet been clarified at the atomic level on the pathogenic mechanism of these toxins or the interaction between a polycyclic ether compounds and a protein. Using the crystal structures of anti-ciguatoxin antibody 10C9 Fab in ligand-free form and in complexes with ABCD-ring (CTX3C-ABCD) and ABCDE-ring (C...

IMPORTANCE Polycyclic aromatic hydrocarbons are common carcinogenic and neurotoxic urban air pollutants. Toxic exposures, including air pollution, are disproportionately high in communities of color and frequently co-occur with chronic economic deprivation. OBJECTIVES We examined whether the association between child IQ and prenatal exposure to polycyclic aromatic hydrocarbons differed betwee...

Two important ingredients of personal care products, namely polycyclic musk fragrances and UV filters, can be found in the environment and in humans. In previous studies, several compounds of both classes have been tested for their interaction with the estrogen receptor. Two polycyclic musk fragrances, namely AHTN and HHCB, turned out to be anti-estrogenic both in vitro and in vivo in a transge...

in this study, the degradation potential of five polycyclic aromatic hydrocarbons (pahs) by aerobic mixed bacterial cultures was investigated. microorganisms were isolated from hydrocarbon contaminated soils of shadegan wetland located in southwest of iran. the degradation experiments were conducted in liquid cultures. pah or pahs concentration was 100 mg/l at the beginning of degradation exper...

in this study, oxic and anoxic microcosms were constructed with aquifer sediment collected from the vicinity of a municipal solid waste composting site.phenanthrene was used as a model pah compound. the changes of bacterial and archaeal communities in microcosms were characterized with terminal restriction fragment length polymorphism. 16s rrna gene clone library analysis was also used to inves...

a fast and simple modified quechers (quick, easy, cheap, rugged and safe) extraction method based on spiked calibration curves and direct sample introduction was developed for determination of benzo[a]pyrene (bap) in bread by gas chromatography-mass spectrometry single quadrupole selected ion monitoring (gc/ms-sq-sim). sample preparation includes extraction of bap into acetone followed by clean...

aims of the study: endometriosis is a prevalent gynecologic disorder in young women at reproductiveage but the underlying risk factors have not identified yet in iran and other neighboringcountries. persistent exposure to environmental endocrine disrupting chemicals (edcs) in particulardioxins, pahs and polychlorinated biphenyls (pcbs) with xenoestrogenic potentials have beenhypothesized in the...