Dental Update – May 2000 165 Abstract: As both humans and fungi are eukaryotic organisms, antifungal agents affect their cellular metabolism. Thus, a relatively few antifungals with minimal toxicity and side-efects are available compared with a plethora of antibacterials. These agents currently prescribed in dentistry belong to two major groups, the polyenes (nystatin and amphotericin B) and th...

The polyenic antibiotic lucensomycin caused a severe inhibition of uridine or thymidine incorporation into RNA or DNA of ascites tumor cells. The inhibition appeared to be related to the ability of the polyene to interact with the cell membrane, the permeability of which was increased; simple leakage of precursors or of enzymes from the cells did not fully account for the kinetics of inhibition...

B . J o h a n n e s * , H . B r z e z i n k a , a n d H . B u d z i k i e w i c z Institut für Organische Chemie der Universität K ö l n Z. Naturforsch. 84b , 300-305 (1979); received N o v e m b e r 7, 1978 MS, Analysis, Carotenoids, Polyene Chain B y examining suitably substituted analogs o f carotenoids the steric and electronic influences governing the elimination of xylene and toluene f r ...

The alterations in the absorption and fluorescence spectra observed for the polyene antibiotics filipin and nystatin in the presence of cholesterol are due to an exciton interaction (polyene aggregates) and cannot be attributed to a specific sterol-antibiotic complex. Filipin and nystatin molecules partition into the sterol aggregates, these structures being very efficient to induce exciton int...

15 A comprehensive comparative analysis of the structure – antifungal activity relationships 16 for the series of biosynthetically engineered nystatin analogues, their novel semisynthetic 17 derivatives, as well as amphotericin B (AMB) and its semisynthetic derivatives was performed. 18 The data obtained revealed the significant influence of the structure of the C7 – C10 polyol 19 region on the...

Heptamethine cyanines are important near-IR fluorophores used in many fluorescence applications. Despite this utility, these molecules are susceptible to light-promoted reactions (photobleaching) involving photochemically generated reactive oxygen species (ROS). Here, we have sought to define key chemical aspects of this nearly inescapable process. Near-IR photolysis of a model heptamethine cya...

A new polyene macrolide antibiotic, YS-822A was isolated from the culture filtrate of a mutant strain H-8 of Streptoverticillium eurocidicum var. asterocidicus S-822. Whereas the original S-822 strain produced not only YS-822 substances but also teleocidin as by-product which is well-known as a strong carcinogenic promoter, the mutagenized H-8 strain produced the antibiotic with only a trace am...

In this work the effect of the γ-radiation dose on ageing of carbon black reinforced elastomeric materials was studied. The compounds based on natural rubber/chlorosulfonated rubber blend (NR/CSM) and butadiene acrylonitrile rubber/chlorosulfonated rubber blend (NBR/CSM) (50:50, w/w) with different loadings (0, 20, 40, 50, 60, 80 and 100 phr) of the filler with the average particle size of 40 n...