Objective(s):Vascular endothelial growth factor (VEGF) has biological actions on energy homeostasis, inflammation and insulin resistance. The present study aimed to investigate the association between VEGF -460 T/C (rs833061), and +936 C/T (rs3025039) polymorphism and risk of non-alcohol fatty liver disease (NAFLD) in Hubei Han population and to further explore the interactions of smoking with ...

Investigating Genetic Diversity and Relationships in some Henbane (Hyoscyamus spp.) Populations Based on Polymorphisms Resulting from Retrotransposon Insertion

background three single nucleotide polymorphisms (snps) near interleukin-28b (il-28b) gene were shown to be highly associated with treatment response (svr) in patients with chronic hepatitis c virus (hcv) infection. there is limited data about the role of single and combined il-28b polymorphisms in hcv-infected polish population. objectives this study's aim was to determine predictability of th...

Background: Subclinical hypothyroidism (SCH) remains largely unnoticed as a major cause of infertility due toasymptomatic. Polymorphisms of phosphodiesterase 8B gene (PDE8B) have been linked with various diseases,including female infertility. Hence, we aimed to study prevalence of SCH, in infertile females, explore associationof PDE8B rs4704397 A/G and rs6885099 G/A polymorphi...

Colour polymorphisms are popular study systems among biologists interested in evolutionary dynamics, genomics, sexual selection and conflict. In many damselfly groups, such as the globally distributed genus Ischnura (forktails), sex-limited female colour occur multiple species. Female-polymorphic species contain two or three morphs, one of which phenotypically matches male (androchrome mimic) o...

Introduction: Vitamin D fulfills its crucial role in cell proliferation and death through signal transduction into the nucleus by vitamin D receptor (VDR). Recent studies have depicted the association between VDR gene polymorphisms and different cancers, including breast cancer. This study attempted to consider the relationship between VDR gene polymorphisms and breast cancer risk among women i...

Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC  chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered immune responses. Deletion of 32 base pai...

Objective(s): Asthma, the most frequent chronic respiratory disease, results from a complex interaction between multiple genes and environmental factors. To date, more than 100 candidate genes and single nucleotide polymorphisms (SNPs) have been reported to be associated with asthma. One of the discovered genes related to asthma is ADAM33. However, the relationship between ADAM33 gene polymorph...

  Objective(s): Non- Hodgkin lymphoma (NHL) and acute lymphoblastic leukemia (ALL) are two main hematological malignances which have been driven from lymphoid tissue. Genetic polymorphisms in tumor necrosis factor-α (TNF-α) -308 and lymphotoxin-α (LT-α) +252 may affect their transcription and expression which leads to their high plasma level. The frequency of the TNF-α (-308) and LT-...