نتایج جستجو برای: polysorbate 20
تعداد نتایج: 609086 فیلتر نتایج به سال:
Synthetic nonionic surfactant vesicles (niosomes) are a colloidal system with closed bilayer structures, displaying distinct advantages in stability and cost compared with liposomes. In this article, polysorbate cationic niosomes (PCNs) were developed as gene carriers. The PCNs comprised nonionic surfactants (i.e., polysorbates) and a cationic cholesterol, and were synthesized using a film hydr...
A substantial increase in the incidence of pure red cell aplasia (PRCA) associated with recombinant human erythropoietin (epoetin) treatment occurred in 1998. The upsurge of antibody-mediated PRCA was almost exclusively associated with chronic kidney disease patients who received subcutaneous epoetin therapy and the formulation of epoetin-alpha distributed outside the USA (EPREX/ERYPO). A syste...
Three multiple water-in-oil-in-water (W/O/W) nanoemulsions have been designed for potential inclusion of either lipophilic or hydrophilic drugs using a two-step emulsification process exclusively based on low-energy self-emulsification. The W/O primary emulsion was constituted by a blend of oil (medium chain triglyceride), a mixture (7:3) of two surfactants, and a 10% water phase. The surfactan...
Abstract Hydrolytic degradation of the polysorbate 20 (PS20) surfactant in protein-based liquid formulations releases free fatty acids (FFAs), which can accumulate to form particles drug products during real-time (long-term) storage. To identify formulation conditions that mitigate risk particle formation, we conducted a longitudinal study using purified recombinant monoclonal antibody (mAb) fo...
BACKGROUND Preparation of nanoformulations using natural products as bioactive substances is considered very promising for innovative larvicidal agents. On this context, oil in water nanoemulsions develop a main role, since they satisfactorily disperse poor-water soluble substances, such as herbal oils, in aqueous media. Pterodon emarginatus, popularly known as sucupira, has a promising bioacti...
the present study was carried out to examine the effects of satureja khuzistanica essential oils(skeo), on cholesterol content, fatty acids composition, and thiobarbituric acid reactive substances,(tbars) concentration of raw breast meat in broiler chickens. a total of 720 one-day-old broilerchicks (cobb 500) were taken as sample to study the effects of six experimental treatments in 6replicate...
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