Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene affect CFTR protein biogenesis or its function as a chloride channel, resulting in dysregulation of epithelial fluid transport in the lung, pancreas and other organs in cystic fibrosis (CF). Development of pharmaceutical strategies to treat CF requires understanding of the mechanisms underlying channel function. Ho...

A polypropylene microporous membrane (PPMM) was fabricated by thermally induced phase separation (TIPS) method. The effects of protein size and structure as well as filtration pressure on the membrane performance and fouling mechanisms were investigated using two different proteins, bovine serum albumin (BSA) and collagen, in dead-end filtration setup. Obtained results showed that, for each pro...

In view of the proliferating applications involving membrane-based separation, inevitable membrane fouling phenomenon is well-studied. However, influence foulant shape on remained incompletely understood. Therefore, goal this study was to investigate behaviors by three different shapes latex particles (namely, peanut, pear and sphere) with similar mean diameters in range 3.5–3.8 ?m. External in...

The ability of DNA to adopt non-canonical structures can affect transcription and has broad implications for genome functioning. We have recently reported that guanine-rich (G-rich) homopurine-homopyrimidine sequences cause significant blockage of transcription in vitro in a strictly orientation-dependent manner: when the G-rich strand serves as the non-template strand [Belotserkovskii et al. (...

BACKGROUND Hydrocephalus is the abnormal accumulation of cerebrospinal fluid within the ventricles and subarachnoid spaces, resulting in increased intracranial pressure. The treatment of choice is placement of ventriculoperitoneal shunt. Ventriculoperitoneal shunt blockage is not an uncommon complication. Objective of the study was to find out the frequency, causes and site of ventriculoperiton...