Cardiovascular complications are a major cause of morbidity and the leading cause of mortality in renal transplant recipients. Multiple cardiovascular risk factors are often present before transplantation. Prior ischaemic heart disease, cerebrovascular disease and peripheral vascular disease predict post-transplantation mortality, as do older age, diabetes mellitus, smoking and length of time o...

INTRODUCTION Early recognition of the signs and symptoms of a heart attack can lead to reduced morbidity and mortality. METHODS A workplace intervention was conducted among 523 Montana state health department employees in 2003 to increase awareness of the signs and symptoms of heart attack and the need to use 911. All employees received an Act in Time to Heart Attack Signs brochure and wallet...

OBJECTIVES This study sought to identify factors that may be associated with help-seeking by witnesses during overdoses where naloxone is administered. SETTING Overdose events occurred in and were reported from the five regional health authorities across British Columbia, Canada. Naloxone administration forms completed following overdose events were submitted to the British Columbia Take Home...

Background and Purpose—Public knowledge of stroke warning signs and risk factors is poor, especially in higher risk groups such as blacks. We sought to design a creative new way to educate black women by working through local beauty salons and measuring the results of the intervention. Methods—Thirty black beauticians were educated about stroke warning signs and risk factors in 2 large urban ar...

OBJECTIVE Stroke is the fifth leading cause of death and the leading cause of serious long-term adult disability in the US. Acute stroke treatments with intravenous thrombolysis and endovascular therapy are proven to reduce disability, however a critical limitation on their effectiveness is the narrow time window for administration, which is 4.5 hours and 6 hours respectively from the onset of ...

PURPOSE To identify a melanoma microRNA (miRNA) expression signature that is predictive of outcome and then evaluate its potential to improve risk stratification when added to the standard-of-care staging criteria. EXPERIMENTAL DESIGN Total RNA was extracted from 59 formalin-fixed paraffin-embedded melanoma metastases and hybridized to miRNA arrays containing 911 probes. We then correlated mi...

CONTEXT AND OBJECTIVES The buccal mucosa presents a unique surface for non-invasive drug delivery and also avoids first-pass metabolism. The objective of this study was the formulation development of polymeric mucoadhesive lyophilized wafers as a matrix for potential buccal drug delivery. MATERIALS AND METHODS Differential scanning calorimetry (DSC) was used to develop an optimum freeze-cycle...

Decoupling Crisis Response from Policing Obtaining care in a mental health crisis should be as routine and assistive calling an ambulance for other crises. Yet too long, 911 f...

Multiple forms of liver microsomal cytochrome P-450 isolated from immature male rats pretreated with phenobarbital or 3-methylcholanthrene are described. A fraction. of low specific content (Fraction A, 1.7 to 4.0 nmol of cytochrome P-450 per mg of protein) and a fraction substantially purified (Fraction B, 9.0 to 11.0 mnol of cytochrome P-450 per mg of protein) are obtained by DEAE-cellulose c...