We examine the expression pattern of ZnT3 in the cerebral and cerebellar areas of mouse brain throughout development. During embryogenesis and early postnatal stages, ZnT3 transcripts were detected in several areas. Label was clear in areas related to proliferation and differentiation. As development proceeded, the label gradually disappeared in these areas and increased in the chelatable vesic...

Fetal detection of adversity is a conserved trait that allows many species to adapt their early developmental trajectories to ensure survival. According to the fetal-programming model, exposure to stressful or hostile conditions in utero is associated with compromised development and a lifelong risk of adverse health outcomes. In a longitudinal study, we examined the consequences of prenatal an...

acyl-CoA synthetase and carnitine acyltransferase I not only exhibit the greatest adaptive responses during development but also show the most dramatic increases in activity in the livers of adult rats subjected to experimental conditions known to result in an increase in hepatic fatty acid degradation (P. A. Chalk & E. Bailey, unpublished work). It seems possible that these enzymes may fulfil ...

Previous studies of alveolarization have used rats or lambs; however, neither closely reflects human alveolar development. We characterized alveolar development in rabbits (n = 3-7 /group) at 28 days gestation (dg) to 9 mo to determine whether they followed the human pattern more closely. The right lung was made up of 30% alveolar and 50% duct space at 28 dg to 3 days and of 50 and 30%, respect...

Increasing numbers of epidemiologic studies associate air pollution exposure in children with decreased lung function development. The objective of this study was to examine the effects of exposure to combustion-generated fine [230 and 212 nm number mean aerodynamic particle diameter (NMAD)] to ultrafine (73 nm NMAD) particles differing in elemental (EC) and organic (OC) carbon content on postn...

DOI 10.1027/0044-3409.216.3.148 Abstract. The spontaneous movements of the newborn infant have a long prenatal history. From 8 weeks postmenstrual age onward the fetus moves in distinct motor patterns. There is no period of amorphic and random movements. The patterns are easily recognizable, as all of them can be seen after birth. The human neonate demonstrates a continuum of motor patterns fro...

Sensory gating represents the nervous system's ability to inhibit responding to irrelevant environmental stimuli. In order to characterize the early development of acoustic sensory gating, suppression of auditory evoked potential component P1 (i.e. P50) in response to paired clicks was measured during REM sleep in healthy infants (1-4 months) that were without genetic risk for disrupted sensory...