Nucleo-cytoplasmic RNA export is an essential post-transcriptional step to control gene expression in eukaryotic cells and is poorly understood in apicomplexan parasites. With the exception of UAP56, a component of TREX (Transcription Export) complex, other components of mRNA export machinery are not well conserved in divergent supergroups. Here, we use Toxoplasma gondii as a model system to fu...

today export diversification has become one of the most important economic objectives of development strategies in the developing countries. for various reasons, such as preventing instability in export prices of primary products in global markets, reducing fluctuations in exchanges of them compared with industrial goods, producing dynamic benefits resulted from exporting various goods and incr...

regarding the importance and high proportion of iranian manufacturing industries' export in nonoil export basket, and their impact on economic growth, it is essential that effective factors on the manufacturing industries' export be investigated. this paper investigates the impact of human capital on the export of iranian industries, using a panel data set of 2-digit isic manufacturing industri...

in this study, the situation of iran, u.s and turkey's pistachio export is investigated. to this purpose, revealed comparative advantage (rca) index is calculated based on agricultural and total economy export, separately, then forecasted by using auto- regressive integrated moving average (arima) approached, for 2008-2013. the results show that considering both commodity baskets, turkey and ir...

This paper applies Export Similarity Index to examine China’s export potential to ASEAN market by comparing China with six main ASEAN member countries (ASEAN 6) and the other main trade partners of ASEAN. It shows that competition is severe on industrial level in ASEAN market, and the bilateral trade potential is uncertain. While accounting for the factors of size, distance and integration etc....

Viruses commonly utilize the cellular trafficking machinery of polarized cells to effect viral export. Hepatocytes are polarized in vivo, but most in vitro hepatocyte models are either nonpolarized or have morphology unsuitable for the study of viral export. Here, we investigate the mechanisms of trafficking and export for the hepadnaviruses hepatitis B virus (HBV) and duck hepatitis B virus (D...

The export protein CRM1 is required for the nuclear export of a wide variety of cancer-related "cargo" proteins including p53, c-Abl, and FOXO-3A. Leptomycin B (LMB) is a highly specific inhibitor of CRM1 with significant in vitro potency but limited in vivo efficacy due to toxicity. We now report a series of semisynthetic LMB derivatives showing substantially improved therapeutic windows. Expo...

Many proteins are transported from the nucleus to the cytoplasm by the exportin CRM1, which recognizes cargo proteins through a leucine rich nuclear export signal (NES). This nuclear export process can be inhibited by several small molecules, both natural products and fully synthetic compounds. The structural basis for the inhibition of nuclear export by leptomycin (LMB) based on disruption of ...

This study provides an in-depth analysis of shifting export specialisation at the SITC 3digit product category level and links this analysis to Malaysian export potential. The paper uses the revealed comparative advantage framework to analyse the extent of export competition between Malaysia and other ASEAN economies. It argues that the degree of competition among ASEAN countries will intensify...