BACKGROUND Reciprocal interactions between epithelium and stroma play vital roles for prostate cancer development and progression. Enhanced secretions of cytokines and growth factors by cancer associated fibroblasts in prostate tumors create a favorable microenvironment for cancer cells to grow and metastasize. Our previous work showed that the progesterone receptor (PR) was expressed specifica...

The conjugates of some dicarboxylic acid hemiesters of triterpenes which show potent inhibition against human immunodeficiency virus type 1 protease (HIV-1 PR) with a reverse transcriptase inhibitor azidothymidine (AZT) or anti-HIV alkaloid FK 3000 were prepared, and their inhibitory activities were investigated against HIV-induced cytopathic effects (CPE) and HIV-1 PR. Most of the triterpene-A...

Most of the allergenic proteins from fruits identified so far belong to different families pathogenesis-related (PR) proteins. These PR have been classified in structurally and functionally unrelated proteins, but majority all fruit allergens three groups, particular PR-5 thaumatin-like (TLP), PR-10 Bet v 1-like PR-14 non-specific lipid transfer (nsTLP). Some can also be found among PR-protein ...

Accepted: September 01, 2014 Study carried out at Hospital do Trabalhador – HT – Curitiba (PR), Brazil. 1 Hospital do Idoso Zilda Arns Curitiba (PR), Brazil. 2 Universidade Tuiuti do Paraná – UTP Curitiba (PR), Brazil. 3 Hospital Infantil Waldemar Monastier Curitiba (PR), Brazil. 4 Hospital do Trabalhador do Paraná – HT Curitiba (PR), Brazil. Financial support: nothing to declare. Conflict of i...

Pityriasis rosea is a short-lived rash that commences initially as a large so-called ‘herald’ patch followed by a rapidly evolving eruption on the trunk and extremities. Characteristic pattern of lesions follow the lines of cleavage in a ‘christmas tree’ distribution. PR is most frequently seen between first and third decade but a range of 3 month to 83 years were reported. The incidence doesn’...

The performance of the adaptive projection receiver (PR), a recently proposed joint detector for CDMA with error control coding, is investigated. It is shown that the adaptive version of the PR performs better than the algebraic PR. A close approximation of the error probability for the adaptive PR is derived. The performance improvement of the adaptive PR, which is of the order of 1-2dB in Eb=...

Steroid receptor coactivator-1 (SRC-1) family members interact with steroid receptors, including estrogen receptor alpha (ERalpha) and progesterone receptor (PR), to enhance ligand-dependent transcription. However, the expression of ERalpha and SRC-1 was found to be segregated in distinct subsets of cells within the epithelium of the estrogen-responsive rat mammary gland. This finding was in co...

A novel platinum-mediated process involving intermolecular activation of a C(aryl)-H bond of toluene, intramolecular activation of an imine C(aryl)-Cl bond and formation of a C-C bond is reported.

Generation of azomethine imine and its scope in regioselective 1,3-dipolar cycloaddition (DC) of imine with PhIO toward highly substituted Delta(2)-1,2,4-triazoline, 1,2,4-triazole, and their fused, chiral, and sugar-based analogues are demonstrated.

To evaluate the characteristics and determinants of partial remission (PR) in Belgian children with type 1 diabetes (T1D), we analyzed records of 242 children from our center. Clinical and biological features were collected at diagnosis and during follow-up. PR was defined using the insulin-dose-adjusted A1C definition. PR occurred in 56.2% of patients and lasted 9.2 months (0.5 to 56.6). 25.6%...