The caffeine-induced impairment of insulin action is commonly attributed to adenosine receptor (AR) antagonism in skeletal muscle. However, epinephrine, a potent inhibitor of insulin actions, is increased after caffeine ingestion. We tested the hypothesis that the insulin antagonistic effects of caffeine are mediated by epinephrine, and not by AR antagonism, in seven healthy men. On four separa...

BACKGROUND Cardiac conduction, as assessed by electrocardiographic PR interval and QRS duration, is an important electrophysiological trait and a determinant of arrhythmia risk. OBJECTIVE We sought to identify common genetic determinants of these measures. METHODS We examined 1604 individuals from the island of Kosrae, Federated States of Micronesia, an isolated founder population. We adjus...

Steroid hormones exert profound effects on the development of brain areas controlling complex cognitive function in adulthood. One class, progestins, may contribute by acting on the progestin receptor (PR), which is transiently expressed in a critical layer of developing cortex: the subplate. PR expression in the subplate coincides with the establishment of ongoing cortical connectivity and may...

A novel platinum-mediated process involving intermolecular activation of a C(aryl)-H bond of toluene, intramolecular activation of an imine C(aryl)-Cl bond and formation of a C-C bond is reported.

Generation of azomethine imine and its scope in regioselective 1,3-dipolar cycloaddition (DC) of imine with PhIO toward highly substituted Delta(2)-1,2,4-triazoline, 1,2,4-triazole, and their fused, chiral, and sugar-based analogues are demonstrated.

Background: Status of tumor receptor, including estrogen receptor(ER), progesterone receptor(PR) and Erb-B2 Receptor Tyrosine Kinase 2(ERBB2), is important to predict clinical behavior in breast cancer. Cutaneous metastasis from cancer a dismal sign. However, whether the receptor status would differ primary skin metastatic sites conversion affect remain unknown. Methods: From 2002 2021, 41 pati...

fibrosis in rats 3 Nan Lin, Si Chen, Weidong Pan ,Linan Xu, Kunpeng Hu, Ruiyun Xu 4 5 1.Department of Hepatobiliary Surgery, the Third Affiliated Hospital, Sun 6 Yat-Sen University, GuangZhou 510630, PR China 7 2.Department of Immunology, Anhui Medical University, HeFei 230032,PR 8 China 9 3 Department of Gynecology and Obstetrics, the First Affiliated Hospital, 10 SunYat-Sen University, GuangZ...

Cells infected with vaccinia viruses expressing the equine infectious anaemia virus (EIAV) gag gene (VGag) or gag plus the 5' pol encoding protease (VGag/PR) were evaluated with monoclonal antibody to a p26 capsid protein linear epitope (QEISKFLTD). Both recombinant viruses expressed Gag precursor protein (55K) whereas only VGag/PR expressed a detectable Gag-Pol fusion protein (82K) with a func...

The reactivity of the amino(cyano)borane (i)Pr(2)NBH(CN) (2) towards [RuH(2)(η(2)-H(2))(2)(PCy(3))(2)] (3) was investigated. Our study reveals that the formation of the bis(isocyanoborane) ruthenium complex [RuH(CN)(CN-BHN(i)Pr(2))(2)(PCy(3))(2)] (6) occurs via the intermediacy of the bis(σ-B-H) ruthenium complex [RuH(CN)(H(2)BN(i)Pr(2))(PCy(3))(2)] (5). This transformation involves BCN linkage...

Of 2744 patients seen in clinic practice, 37 were found to have a prolonged PR interval. The causes of prolongation of the PR interval were: congenital heart disease, 6; chronic rheumatic heart disease, 2; digitalis induced, 4; miscellaneous, 5; and coronary heart disease, 20. Of the 20 associated with coronary heart disease, 8 (2I.6% of all the patients with prolonged PR interval) had myocardi...