BACKGROUND AND PURPOSE The purpose of this study was to characterize abnormal cortical activity during sleep in restless legs syndrome (RLS) patients and to determine the effects of treatment with a dopamine agonist. Based on whole-brain electroencephalograms, we attempted to verify alterations in the functional network as well as the spectral power of neural activities during sleep in RLS pati...

BACKGROUND Motor fluctuations and dyskinesias can cause disability and reduce quality of life for patients with Parkinson disease (PD). OBJECTIVES To evaluate factors associated with the development of motor fluctuations and dyskinesias and to assess the sequence in which they occur in individual patients. DESIGN We performed a retrospective analysis of data from a randomized clinical trial...

BACKGROUND To determine if testosterone levels are influenced by dopaminergic therapy in Parkinson disease (PD) patients. Testosterone level has been reported to be low in patients with PD and other neurodegenerative diseases. In this study, we sought to determine whether dopaminergic therapy (i.e. levodopa and dopamine agonist) influenced testosterone levels. We used a cohort of consecutive ma...

Background: This study was aimed to evaluate the efficacy of pramipexole combined with ganglioside for PD treatment and monotherapy, so as provide reference clinical practice. 
 Methods: 61 patients selected from June 2019 December 2020 at our hospital were divided into two groups. The control group (n=31) given dopasizide oral treatment, (n=30) pramipexole. efficacy, adverse reactions, mo...

The efficacy and safety of pramipexole have been reported both in the treatment unipolar/bipolar depression anxiety/depression patients with Parkison disease. But, there is no evidence for its clinical effect seasonal depressive disorder. In this case report, patient responded to presented.

Once a day push pull osmotic tablets containing pramipexole as an antiparkinson’s agent were developed and evaluated for in vivo efficacy. Push pull osmotic tablets are bilayered tablets consisting of pull layer (drug layer) and push layer (polymer layer) coated with semipermeable cellulose acetate membrane containing water leaching pore forming agents. To determine the in vivo efficacy of form...

O ver 350 neurologists from all over the world converged on Cannes, France in October for the 3rd International Scientific Symposium on Parkinson’s Disease and Restless Legs Syndrome. The two-day symposium was supported by an unrestricted educational grant from Boehringer Ingelheim and accredited by the European Federation of Neurological Societies (EFNS). Welcoming delegates to the first day o...

Animal findings have highlighted the modulatory role of phasic dopamine (DA) signaling in incentive learning, particularly in the acquisition of reward-related behavior. In humans, these processes remain largely unknown. In a recent study, we demonstrated that a single low dose of a D2/D3 agonist (pramipexole)-assumed to activate DA autoreceptors and thus reduce phasic DA bursts-impaired reward...