BACKGROUND Neurocysticercosis, infection of the brain with larvae of Taenia solium (pork tapeworm), is one of several forms of human cysticercosis caused by this organism. We investigated the role of albendazole and praziquantel in the treatment of patients with parenchymal neurocysticercosis by performing a meta-analysis of comparative trials of their effectiveness and safety. METHODS AND PR...

Several cases of therapeutic failure of praziquantel used for the treatment of urinary schistosomiasis have been reported. Alternative drugs, like niridazol and metrifonate, have shown a lower therapeutic effect and more side effects than praziquantel. Twenty-six Brazilian military men (median age of 29 years) with a positive urine parasitological exam who were part of a United Nation peace mis...

In 2014, an estimated 40 million women of reproductive age were infected with Schistosoma haematobium, S. japonicum and/or S. mansoni. In both 2003 and 2006, the World Health Organization (WHO) recommended that all schistosome-infected pregnant and breastfeeding women be offered treatment, with praziquantel, either individually or during treatment campaigns. In 2006, WHO also stated the need fo...

The reliance on a single drug to treat a population of over 200 million people infected and over 700 million people at risk over three continents seems particularly perilous when considering the threat of drug resistance. An important shortcoming of praziquantel is its relative inactivity against migratory juvenile and subadult worms. Antischistosomal properties of the antimalarial drug, mefloq...

Background Urogenital schistosomiasis due to Schistosoma hematobium infection is hypothesized to cause increased HIV-1 RNA shedding in semen in HIV co-infected men as result of chronic egg-induced inflammation in the prostate and the seminal vesicles. The effect of treatment with the antihelminthic agent praziquantel on seminal HIV-1 RNA load was assessed in this study. Methods HIV-1 RNA load...

BACKGROUND There is evidence from experimental models that the praziquantel-induced clearance of schistosomiasis is dependent on the host's immune response. Consequently, human immunodeficiency virus (HIV)-related immunodeficiency may impair the effect of praziquantel treatment. METHODS In a prospective cohort study, schistosome-infected subjects who were or were not coinfected with HIV were ...

Dirofilaria immitis and repens are mosquito-borne pathogens responsible for dirofilariasis in humans animals. Their transmission spread depend on the activity of vectors frequency hosts a given area. Here, we investigated efficacy monthly multimodal prophylactic (MMP) strategy against canine Corsica Island (France). The study was conducted as evidence an trial which eighty dogs were divided int...

The aim of this study was to evaluate the efficacy dietary praziquantel (PZQ), a promising fish anthelminthic, against Zeuxapta seriolae, lethal ectoparasite greater amberjack (Seriola dumerili Risso) farmed in Mediterranean and elsewhere. trial carried out small cages (3 m3) situ, harbouring (125 ± 14 g) naturally infected with Z. at 25 1 °C water temperature. Praziquantel-medicated diet (150 ...

BACKGROUND Approximately 200 million people worldwide harbour parasitic flatworm infections that cause schistosomiasis. A single drug-praziquantel (PZQ)-has served as the mainstay pharmacotherapy for schistosome infections since the 1980s. However, the relevant in vivo target(s) of praziquantel remain undefined. METHODS AND FINDINGS Here, we provide fresh perspective on the molecular basis of...

Despite attempts to control intestinal schistosomiasis through school-based mass drug administration (MDA) with praziquantel using school teachers in Uganda, less than 30% of the school children take the treatment in some areas. The aim of the study was to understand why the uptake of praziquantel among school children is low and to suggest strategies for improved uptake. This was a cross-secti...