2-n-propylquinoline is presently a drug-candidate for the treatment of visceral leishmaniosis in pre-clinical development. As this compound is in an oily state, it needs to be formulated and the objectives of this study are: to prepare a formulation; to demonstrate that the new salted formulation did not alter the activity of the active ingredient; and finally, that this activity was quite good...

We consider a problem of optimal order allocation faced for example by an internet trading agent who seeks to ful…l an order for speci…ed amounts of several products from a pre-arranged list of suppliers, taking into account availability and price. We present a mixed integer programming (MILP) formulation for the case that suppliers impose a …xed charge which is waived or discounted on orders a...

objective(s): irinotecan is a potent anti-cancer drug from camptothecin group which inhibits topoisomerase i. recently, biodegradable and biocompatible polymers such as poly lactide-co-glycolides (plga) have been considered for the preparation of nanoparticles (nps). materials and methods: in this study, irinotecan loaded plga nps were fabricated by an emulsification/solvent diffusion method to...

OBJECTIVES Buffered low-dose sublingual transmucosal zolpidem lozenge hemitartrate (ST zolpidem) is being developed for the treatment of middle-of-the-night insomnia. The objective of this double-blind placebo-controlled cross-over study (n = 24) was to evaluate the pharmacokinetics (PK) and daytime-sedative profile of 1.0, 1.75, and 3.5 mg dose of the formulation. METHODS Daytime sedation wa...

Rationale: Table compression process has a profound effect on different quality attributes of table manufacturing process such as appearance, content uniformity, hardness, thickness, friability, Disintegration time and Dissolution time. Among all the table compression parameters, feeder speed, precompression, main compression forces and Turret speed have a substantial effect on tablet propertie...

INTRODUCTION Medication changes involving levothyroxine-either dose titrations or switching formulations-occur frequently in patients with erratic thyroid-stimulating hormone (TSH) levels and persistent hypothyroid symptoms. We investigated whether switching patients from levothyroxine tablets to a gel cap formulation of levothyroxine might reduce dose adjustments and improve tolerability and e...

The rationale of this project work is to formulate oral herbal tablets of Cinchona officinalis extract containing quinine and also with pure synthetic quinine, further to determine the pharmacokinetic profile for both and compare. The concentration of quinine in the extract was estimated by HPTLC with comparison to synthetic form. Tablets were prepared from both extract and synthetic form throu...

This paper presents a formulation of the facilities block layout problem which explicitly considers uncertainty in material handling costs on a continuous scale by use of expected values and standard deviations of product forecasts. This formulation is solved using a genetic algorithm meta-heuristic with a flexible bay construct of the departments and total facility area. It is shown that depen...