context different approaches are routinely applied in the treatment of concomitant cholecystocholedocholithiasis. most patients are treated by preoperative endoscopic sphincterotomy followed by laparoscopic cholecystectomy in a two-stage approach. however one-stage approach carrying out intraoperative endoscopic sphincterotomy (ioes) is emerging as a minimally invasive alternative option. our r...

OBJECTIVE An attempt to define pre-osteoarthritis (OA) versus early OA and definitive osteoarthritis. METHODS A group of specialists in the field of cartilage science and treatment was formed to consider the nature of OA onset and its possible diagnosis. RESULTS Late-stage OA, necessitating total joint replacement, is the end stage of a biological process, with many previous earlier stages....

Background: Recent improvement in treatments of cancer has significantly increased survival rates of cancer patients. Unfortunately these treatments such as chemotherapy and radiotherapy can sever damage to the ovaries. Ovarian cryopreservation prior to chemo/ radiotherapy and auto-transplantation post-treatment can restore fertility to cancer patients. Hypoxia in the transplant from delayed re...

Based on the first implementation of mixing antibiotics into bone cement in the 1970s, the Endo-Klinik has used one stage exchange for prosthetic joint infection (PJI) in over 85% of cases. Looking carefully at current literature and guidelines for PJI treatment, there is no clear evidence that a two stage procedure has a higher success rate than a one-stage approach. A cemented one-stage excha...