We develop a novel dose-finding method for two-agent combination phase I trials on the basis of the shrunken predictive probability of toxicity. In this method, a shrinkage logistic regression model that allows distinct shrinkage multipliers for the coefficients of the main effects of two agents and their interaction on the probability of toxicity constructs the toxicity outcome. We also propos...

in this paper, by considering a squint angle for synthetic aperture radar in the strip-map mode, a method is proposed for estimating parameters of a fixed acceleration moving target. non-zero doppler centroid and range-azimuth coupling in the squint mode add complexity to estimation equations of moving target parameters and cause doppler ambiguity. this, in turn, causes to lose the efficiency o...