Amyloidosis is characterised by the extracellular deposition of abnormal protein fibrils. Recent advances in the study of amyloidosis have been based on the chemical analysis of these protein fibrils.1,2 This has also led to a more rational classification of the condition (Fig 1). Further discussion of localised forms of amyloidosis is outside the scope of this article, which will be confined t...

Primary, localised orbital amyloidosis has been reported previously in only 15 patients. A case with amyloidosis strictly localised to an extraocular muscle is presented.

Infiltrative heart diseases are caused by a heterogeneous group of disorders; amyloidosis and sarcoidosis are two frequent causes of myocardial infiltration, which differ in clinical and biological outcome and treatment issues. The presence of high levels of angiotensin-converting enzyme (ACE) in a patient with infiltrative heart disease may increase suspicion of sarcoidosis. Nevertheless, no m...

Introduction. Primary amyloidosis is a disorder resulting from the deposition of fibrillary protein in extracellular tissue. Diagnosis of primary amyloidosis in the celiac/para-pancreatic lymph nodes via endoscopic ultrasound-guided fine needle aspiration has not been reported in the literature. In this article, we report our first observation. Our patient is a 64-year-old Caucasian man who was...

Objective: To evaluate and assess patients with primary cutaneous amyloidosis with regard to sex, age and clinico-pathologic features in the local population. Design: Retrospective case study. Setting: Social hygiene clinic in Tuen Mun, New Territories, Hong Kong. Patients: Chinese patients with a clinical +/histological diagnosis of primary cutaneous amyloidosis: lichen amyloidosis and macular...

CONTEXT Primary amyloidosis, also known as AL amyloidosis, is commonly caused by clonal expansion of plasma cells in the bone marrow, thereby segregating light chains of clonal immunoglobulin that settle in tissues in the form of insoluble amyloid fibrils. The aim of this study was to report a case of primary amyloidosis with renal failure, diagnosed in Hospital São João, Porto, Portugal, focus...

Amyloidosis is a rare disease with an incidence of approximately 6–10 cases per million person years. It is defined as tissue deposition of fibrils consisting of different types and weight of normal serum proteins’ subunits. Amyloidosis disease can involve different organs depending on the subtype. Amyloidosis frequently affects the heart, kidneys, gastrointestinal organs and nervous system. Am...

The case is reported of a woman who died at the age of 36 years from obstructive respiratory failure due to diffuse tracheobronchial amyloidosis which had caused symptoms for six years. When first seen her symptoms of wheezing cough and mucopurulent sputum sometimes streaked with blood were of recent onset, but on bronchogram and bronchoscopy her disease was already widespread. Appearances at b...

CONTEXT Pancreatic involvement in systemic light chain (AL)-amyloidosis is exceedingly rare. Prior reports of endoscopic ultrasound (EUS) for the diagnosis of amyloidosis are also limited. CASE REPORT We report the first description of EUS-guided fine needle aspiration (FNA) for the diagnosis of primary AL-amyloidosis involving the pancreas. CONCLUSION EUS-FNA can be effectively utilized fo...