OBJECTIVE Primary central nervous system lymphoma (PCNSL) is a specific type of non-Hodgkin lymphoma with poor prognosis. The rare incidence of this disease and difficulty to obtain sufficient tissue material impede deep research into PCNSL. However, application of modern molecular techniques makes it possible to find biological characteristics exclusive to PCNSL. Therefore, we systematically r...

Osteopontin (OPN) is the most upregulated gene in primary central nervous system lymphoma (PCNSL) compared to non-CNS diffuse large B cell lymphoma (DLBCL). We show here that OPN is a key mediator of intracerebral tumor growth, invasion, and dissemination in CNS lymphoma, and that these effects depend upon activation of NF-κB. We further show that activation of NF-κB by OPN occurs through a uni...

Primary central nervous system lymphoma (PCNSL), a highly malignant and infrequent tumor, is rarely found within the fourth ventricle. Here we report a case of isolated lymphoma within the fourth ventricle: a 61-year-old male presented with headache, mental disorder, abnormal gait and urinary incontinence. Based on the clinical symptoms and neuroimage, He was initially diagnosed as choroid plex...

purpose: to record the mri features of primary central nervous system lymphoma (pcnsl) and compare these properties in monofocal and multifocal disease. methods: eleven cases of monofocal disease were compared to 9 cases of multifocal disease. all patients were examined by non-enhanced and contrast-enhanced mri. tumor location, signal intensity, enhancement characteristics, age distribution, pe...

Up until the late 1970s, radiation therapy played an important role in the treatment of primary central nervous system lymphoma (PCNSL) but more recently its role has changed due to the increased use of systemic chemotherapy. In this article, the current status of radiotherapy for PCNSL and optimal forms of radiotherapy, including the treatment volume and radiation dose, are discussed. Data fro...

Primary central nervous system lymphomas (PCNSLs) are rare non‐Hodgkin tumors defined as lymphomas of the central nervous system (CNS) without primary tumor elsewhere. It was reported that PCNSLs represented only 3–7% of primary brain tumors and 1–5% of all lymphomas.[1,2] Most of PCNSLs are B-cell lymphomas, while T-cell PCNSL (T-PCNSL) is extremely rare, the majority of the reported T-PCNSL c...