PAPER DISCUSSION Background and Study Aims: In a subgroup of patients, primary sclerosing cholangitis (PSC) is complicated by high-grade focal strictures of the bile ducts, and this can have an unfavourable influence on the natural course of the disease. The aim of this

This case report describes the previously undocumented association between fibrolamellar hepatocellular carcinoma and ulcerative colitis complicated by primary sclerosing cholangitis.

BACKGROUND AND AIM Patients with primary sclerosing cholangitis (PSC) are at high risk for the development of cholangiocarcinoma (CC). Analysis of micro ribonucleic acid (MiRNA) patterns is an evolving research field in biliary pathophysiology with potential value in diagnosis and therapy. Our aim was to evaluate miRNA patterns in serum and bile of patients with PSC and/or CC. METHODS Serum a...

ORTHOTOPIC liver transplantation (OLTx) has emerged during. the last decade to be the most effective therapy for patients with advanced primary sclerosing cholangitis (PSC).1-3 The potential risk of developing cholangiocarcinoma (CCA) in these patients triggered the current study to define the clinical characteristics of patients with concomitant CCA and its effect on patient survival after tra...

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown origin which eventually results in liver cirrhosis. The disease is reported to be more common among the Western population than in the Asian population. Asian experience remains limited. Diagnosis and treatment standards in the Far East have largely followed those in the West, including liver transplantation....

Twenty-nine patients with primary sclerosing cholangitis were reviewed. Males predominated (2:1). Seventy-six per cent presented with cholestasis and cholangitis, 17% with cirrhosis and portal hypertension, and 7% were asymptomatic, presenting with a raised serum alkaline phosphatase. The serum immunoglobulin IgM concentration was raised in 45% of the patients, but no patient had serum mitochon...

A 22 year oldman developed sclerosing cholangitis within two months of documented HIV-1 seroconversion. Sclerosing cholangitis should be included in the differential diagnosis of causes of abdominal pain and raised alkaline phosphatase enzyme levels in HIV-1 antibody positive patients without established CDC

In our case, we present a case of an 80-year-old male who was referred to the gastroenterologist for evaluation suspicious mass. CT imaging at time had shown intrahepatic and extrahepatic biliary dilations, patient thought have pancreatic or common bile duct A mass biopsy showed no malignancy, further warranted. The found elevated IgG4 levels diagnosed with IgG4-sclerosing cholangitis (IgG4-SC)...